# MLB Prediction – Cleveland Guardians vs Minnesota Twins

> OddsTrader AI prediction for Cleveland Guardians vs Minnesota Twins. Includes predicted score,
> expected value (EV), cover probability, bet rating, and best available line.
> Cleveland Guardians (88-74) vs Minnesota Twins (70-92).
> All odds in American format. Last updated: 2025-09-22T14:10:00-07:00.
>
> - League: MLB
> - Event: Cleveland Guardians vs Minnesota Twins
> - Event ID: 4748583
> - Game Date: Sun 09/21 7:10 AM
> - Timezone: America/Los_Angeles
> - Generated At: 2026-06-27T01:17:43.078206-07:00
> - Last Updated: 2025-09-22T14:10:00-07:00

## Cleveland Guardians at Minnesota Twins

**Time:** Sun 09/21 7:10 AM
**Predicted Score:** Minnesota Twins 3, Cleveland Guardians 5
**Records:** Minnesota Twins 70-92 | Cleveland Guardians 88-74

| Market | Pick | EV | Cover Prob. | Bet Rating | Best Line | Sportsbook |
|--------|------|----|-------------|------------|-----------|------------|
| Total | Under | +9.0% | 60% | ★★★★★ | u8.5 (-104) | - |
| Moneyline | CLE | +4.8% | 61% | ★★★★☆ | -130 | - |
| Run Line | CLE | +0.7% | 45% | ★★☆☆☆ | -1.5 (125) | - |
| Run Line | MIN | -3.4% | 55% | ★☆☆☆☆ | +1.5 (-140) | - |
| Moneyline | MIN | -6.3% | 39% | ☆☆☆☆☆ | 122 | - |
| Total | Over | -23.0% | 30% | ☆☆☆☆☆ | o8.5 (-115) | - |

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*Source: [OddsTrader Prediction](https://www.oddstrader.com/mlb/matchups/cleveland-guardians-vs-minnesota-twins-2025-09-21-e4748583/prediction) · Updated Monday, September 22, 2025*