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The upcoming clash on December 6, 2025, between the Duke Blue Devils and Virginia Cavaliers at Bank of America Stadium in Charlotte, NC, promises an exciting showdown in the 2025-26 NCAAF season. This Saturday football game is set to be broadcast on ABC, making it a must-watch event for college football fans and bettors alike.
Our expert picks for the game favor the Virginia Cavaliers, who are predicted to win with a score of 32-27 against the Duke Blue Devils. The prediction model shows a strong hit rate of 53.6% on the point spread market, which supports Virginia -3 as the best bet. Additionally, the moneyline market highlights a 64.8% hit rate favoring Virginia, indicating a valuable betting opportunity.
Over the last 10 games, our predictions have been profitable, especially in the point spread market, which has shown consistent EV and cover percentages. This track record provides bettors with confidence in making informed decisions for the Duke Blue Devils vs Virginia Cavaliers game. For more detailed analysis and picks, check out our comprehensive NCAAF picks and predictions.
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![]() Jacksonville State 8-429% -1½ -103Caesars | |||||||
![]() James Madison 11-150% -21½ -114FanDuel | |||||||
#24Tulane 10-254% +2½ -105BetMGM | |||||||
![]() Boise State 8-4100% -3½ -105Bet365 | |||||||
![]() #5Texas Tech 11-139% -13 -110Bet365 | |||||||
![]() Western Michigan 8-425% -2½ -110Bet365 | |||||||
#10Alabama 10-252% +2½ -104FanDuel | |||||||
![]() #18Virginia 10-228% -2½ -122FanDuel | |||||||
![]() #1Ohio State 12-064% -5½ -110Caesars |
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