Indiana Hoosiers vs Ohio State Buckeyes Picks

The upcoming Saturday football showdown on December 6, 2025, features the Indiana Hoosiers taking on the Ohio State Buckeyes at Lucas Oil Stadium in Indianapolis, IN. This NCAAF regular season Week 15 game promises to be a thrilling contest broadcast on Fox, perfect for fans and bettors alike.

Our expert picks favor the Ohio State Buckeyes to win with a predicted score of 28-21, expecting Ohio State to cover a -4 spread. The projected total score is around 49.7 points, suggesting an exciting, high-scoring game. Our betting tips highlight the Ohio State moneyline and the over 46.5 total as strong options, with the over market boasting a 56.4% hit rate and positive EV, signaling profitable opportunities for bettors.

In recent form, Ohio State has shown strength with 6 wins in their last 10 games on the moneyline, while Indiana has also performed well, winning 6 of their last 10 games straight up. This solid track record from both teams adds confidence to our predictions.

For bettors looking to make informed decisions, these stats and insights can help identify value bets and maximize returns. Don't miss detailed NCAAF picks and predictions on our dedicated page for more expert analysis. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.