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Nov 16, 2025 4:05 PM EST
Week 11
SF
-3 (+100)o48½ (-110)
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San Francisco 49ers vs Arizona Cardinals Betting Trends
Updated:Nov 13, 2025 1:47 AM EST
The upcoming NFL showdown on November 16, 2025, features the San Francisco 49ers visiting the Arizona Cardinals at State Farm Stadium in Glendale, AZ. This Sunday football game promises intriguing betting trends and compelling game insights for bettors and fans alike. The 49ers, favored by a 3-point spread with odds of -112 at Caesars, face a Cardinals squad eager to leverage their home advantage under the retractable dome.
Quarterback Brock Purdy, listed as questionable but likely to play for the 49ers, contrasts with the Cardinals' Jacoby Brissett starting in place of injured Kyler Murray, who remains on injured reserve. The 49ers boast a strong passing offense averaging 261.4 yards per game against the Cardinals' defense, which allows about 225.3 passing yards. Meanwhile, Arizona's run offense averages 113.4 yards, facing a 49ers run defense yielding roughly 110.6 yards per game, setting up a balanced ground game battle.
Pass protection for the 49ers is solid with Trent Williams leading the offensive line, facing a Cardinals pass rush that records 13.8 sacks per game. The Cardinals' offensive line, with some questionable starters, faces a 49ers pass rush allowing just 7.7 sacks. Recent form favors San Francisco, winning 6 of their last 10 games straight up, while Arizona struggles with a 3-6 record. The total points line is set at 48.5, with the under favored at -114, suggesting a potentially tight defensive game.
In their last matchup on September 21, 2025, the 49ers narrowly edged the Cardinals 16-15 in a defensive slugfest. The Cardinals have a slightly better ATS record (5-4) than the 49ers (5-5), adding another layer of intrigue to betting strategies. This game will be broadcast on FOX, making it accessible for fans nationwide.
These betting trends and sports insights highlight key factors like quarterback health, offensive line matchups, and defensive strengths that bettors can use to make informed wagers. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
ATS Records
All
5-5 (15th)Against the Spread5-4 (11th)
6-4 (12th)Straight Up3-6 (22nd)
+3.3Straight Up Units-3.9
7-3Over / Under5-4
TEAM MATCHUP
OFF
DEF
OFF
DEF
22Points22.4
10.9First Half12.3
11.1Second Half10.1
3.3First Quarter4.8
7.6Second Quarter7.6
3.8Third Quarter6.1
7Fourth Quarter4
356.2Total Yards316.3
5.5Yards Per Play5.5
261.4Passing Yards202.9
24.9 - 36.2 (68.8%)Completions-Attempts22.8 - 35.3 (64.5%)
6.9Yards Per Passing Play5.2
1.8 (12)Sacks (Yards)3.8 (28)
94.8Rushing Yards113.4
27Attempts25.2
3.5Yards Per Rush4.5
21.61st Downs19.7
13.9Passing11.9
6.3Rushing5.9
1.4Penalties1.9
6 / 12.9 (46.5%)3rd Down6.2 / 13.9 (44.8%)
0.8 / 1.5 (53.3%)4th Down0.7 / 1.4 (46.2%)
2.1 / 3.5 (60%)Red Zone2.3 / 4.1 (56.8%)
6.1 (46.7)Penalties (Yards)6.8 (48.9)
0.6Turnovers1.3
0.1Interceptions0.7
0.5Fumbles Lost0.7
65Total Plays64.3
5.2Kickoffs5.1
3.1Returns4.2
79.3Return Yards104.6
25.6Yards Per Return24.8
2.9Punts3.6
1.7Returns1.2
17.6Return Yards14.2
10.4Yards Per Return11.6
Priority Injuries
PRIORITYRicky Pearsall
Questionable
1 Wide Receiver
PRIORITYBrock Purdy
Questionable
13 Quarterback
PRIORITYMarvin Harrison Jr.
Out
18 Wide Receiver
PRIORITYKyler Murray
Injury Reserve
1 Quarterback
PRIORITYJames Conner
Injury Reserve
6 Running Back
Recent Results
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NFLWeek 11
 New England 8-225% -12½ -118FanDuel | |||||||
 Miami 3-767% -2½ -115Bet365 | |||||||
 N.Y. Giants 2-864% +7 -104FanDuel | |||||||
 Buffalo 6-359% -5½ -110Bet365 | |||||||
 Pittsburgh 5-465% -5½ -110Bet365 | |||||||
 Tennessee 1-878% +7 -117SugarHouse | |||||||
 Minnesota 4-529% -2½ -115Caesars | |||||||
 Atlanta 3-620% -3½ -105Bet365 | |||||||
 Jacksonville 5-446% +3 -114BetRivers | |||||||
 L.A. Rams 7-254% -3 -109BetRivers | |||||||
 Arizona 3-675% +3 -102Caesars | |||||||
 Cleveland 2-785% +8 -117SugarHouse | |||||||
 Denver 8-270% +4 -114BetRivers | |||||||
 Philadelphia 7-273% -2½ -114FanDuel | |||||||
 Las Vegas 2-791% +3½ -114Caesars |
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