Nov 16, 2025 4:05 PM EST

Week 11

San Francisco

3-6

Arizona

-3 (-105)o48 (-118)

FOX

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Arizona Cardinals vs San Francisco 49ers Odds

Updated:Nov 12, 2025 1:36 AM EST

The upcoming NFL matchup between the Arizona Cardinals and San Francisco 49ers is set for November 16, 2025, at State Farm Stadium in Glendale, AZ. This Sunday football game promises to be an exciting encounter with plenty of betting action. The 49ers currently hold the favorite status with a point spread of -2½ -122, while the Cardinals are the underdogs at +2½ 102. Opening odds had the 49ers at -3 -110, so the line has moved slightly, indicating some shifting confidence among bettors. The total is set at 48½ with the under favored at -112, reflecting expectations of a moderately high-scoring game.

For those looking to place a wager, understanding these odds and betting lines is crucial to making smart bets. The 49ers' slight odds adjustment suggests a tighter contest than initially expected, while the Cardinals' position as underdogs offers potential value. This game will be broadcast on FOX, making it easy to catch all the action live. The venue, State Farm Stadium in Glendale, AZ, is known for its retractable dome, which could influence game conditions.

Check out the full NFL odds on our NFL odds page to compare all available lines and find the best bets. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

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Personalize your notifications and get updates on the teams, players or events you care about most. THU 11/138:15 PM N.Y. Jets 2-7 75% +13 -105BetMGM
New England 8-2 25% -12½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/169:30 AM Washington 3-7 33% +2½ +100Caesars
Miami 3-7 67% -2½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/161:00 PM Green Bay 5-3-1 36% -7 -110Caesars
N.Y. Giants 2-8 64% +7 -104FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/161:00 PM Tampa Bay 6-3 41% +5½ -107Caesars
Buffalo 6-3 59% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/161:00 PM Cincinnati 3-6 35% +5½ -107Caesars
Pittsburgh 5-4 65% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/161:00 PM Houston 4-5 22% -6 -110Bet365
Tennessee 1-8 78% +7 -117SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/161:00 PM Chicago 6-3 71% +3 -125BetMGM
Minnesota 4-5 29% -2½ -115Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/161:00 PM Carolina 5-5 80% +3½ -110FanDuel
Atlanta 3-6 20% -3½ -105Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/161:00 PM L.A. Chargers 7-3 54% -3 -105Caesars
Jacksonville 5-4 46% +3 -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/164:05 PM Seattle 7-2 46% +3 -109Caesars
L.A. Rams 7-2 54% -3 -109BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/164:05 PM San Francisco 6-4 25% -3 +100Bet365
Arizona 3-6 75% +3 -102Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/164:25 PM Baltimore 4-5 15% -7½ -109Caesars
Cleveland 2-7 85% +8 -117SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/164:25 PM Kansas City 5-4 30% -3½ -110Bet365
Denver 8-2 70% +4 -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/168:20 PM Detroit 6-3 27% +2½ +100Caesars
Philadelphia 7-2 73% -2½ -114FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. MON 11/178:15 PM Dallas 3-5-1 9% -3½ -102BetMGM
Las Vegas 2-7 91% +3½ -114Caesars

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