Arizona Cardinals vs San Francisco 49ers Player Props

The upcoming NFL showdown on November 16, 2025, between the Arizona Cardinals and San Francisco 49ers at State Farm Stadium in Glendale, AZ, promises an engaging Sunday football experience. This Week 11 matchup offers a fascinating clash of styles, with the Cardinals' dynamic passing offense facing off against the 49ers' resilient pass defense. On the ground, the 49ers' rushing attack led by Christian McCaffrey, who has a strong player props prediction for rushing yards, will challenge Arizona's run defense. Meanwhile, the Cardinals' pass protection will be tested by San Francisco's aggressive pass rush, setting the stage for strategic battles on both sides of the ball.

Our player props and prop bets highlight several opportunities, including Trey McBride's over 69.5 receiving yards, which carries a hit rate of 58.3% and a positive EV of 4.8%. Christian McCaffrey's rushing yards prop also stands out, with an under 71.5 rushing yards offering a 56.4% hit rate and positive EV of 3.1%. These projections are based on detailed player projections and have performed well in recent games, giving bettors an edge.

The game will be broadcast on FOX, making it easily accessible for fans and bettors alike. For those looking to dive deeper into the NFL player props, our comprehensive NFL player props page is a great resource. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.