San Francisco 49ers vs Arizona Cardinals Game Props

The upcoming NFL showdown on November 16, 2025, between the Arizona Cardinals and San Francisco 49ers at State Farm Stadium in Glendale, AZ, promises an exciting Sunday football experience. Fans and bettors alike will be tuning in to FOX for this thrilling REG Week 11 clash. This game offers a rich array of game props, perfect for those looking to capitalize on prop bets and team props.

The Cardinals' pass offense will face a tough challenge against the 49ers' formidable pass defense, creating interesting dynamics for passing touchdowns and field goals. Meanwhile, the 49ers' run offense will test Arizona's run defense, and the battle between the 49ers' pass protection and the Cardinals' aggressive pass rush will be a key factor in this matchup. These elements all contribute to the game projections and totals that bettors should consider.

Our prop bet analysis indicates a high EV on the total touchdowns market, with a strong hit rate in the last 10 games, making it a promising choice for bettors. The pace of play suggests an engaging game with multiple scoring opportunities. For those looking to dive deeper into player performances, our detailed player props page offers valuable insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.