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The upcoming NFL showdown on November 16, 2025, features the Arizona Cardinals vs San Francisco 49ers at State Farm Stadium in Glendale, AZ. This game, part of the 2025-26 NFL regular season Week 11, is a classic home vs away battle. The 49ers have the advantage of playing in a retractable dome stadium, which means weather conditions like rain and wind will not impact their gameplay directly. However, bettors should consider the Cardinals' historical performance in rainy and wet conditions, as outdoor weather can influence their strategy and execution.
Despite the forecast predicting rain and partially cloudy skies with temperatures around the mid-60s, the dome roof of State Farm Stadium will shield players from these elements. Winds are mild from the southwest, around 4.7 to 6.9 mph, which typically wouldn't affect an indoor game. This setup neutralizes one of the usual home field advantages related to weather, placing more emphasis on team skill and preparation.
Arizona Cardinals have shown some vulnerability in wet weather games in the past, which could be a factor in this match if it were outdoors. Meanwhile, the San Francisco 49ers, having played their home games indoors, are accustomed to consistent conditions, which can favor a steady game plan. Bettors can leverage this weather insight alongside team performance trends to make smarter wagers.
Catch this exciting Sunday football game broadcasted on FOX. For more detailed weather conditions and betting insights, visit our NFL weather page and get the best odds at SugarHouse. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
New England 8-225% -12½ -118FanDuel | |||||||
Miami 3-767% -2½ -115Bet365 | |||||||
![]() N.Y. Giants 2-864% +7 -104FanDuel | |||||||
Buffalo 6-359% -5½ -110Bet365 | |||||||
![]() Pittsburgh 5-465% -5½ -110Bet365 | |||||||
![]() Tennessee 1-878% +7 -117SugarHouse | |||||||
Minnesota 4-529% -2½ -115Caesars | |||||||
![]() Atlanta 3-620% -3½ -105Bet365 | |||||||
Jacksonville 5-446% +3 -114BetRivers | |||||||
![]() L.A. Rams 7-254% -3 -109BetRivers | |||||||
Arizona 3-675% +3 -102Caesars | |||||||
Cleveland 2-785% +8 -117SugarHouse | |||||||
Denver 8-270% +4 -114BetRivers | |||||||
Philadelphia 7-273% -2½ -114FanDuel | |||||||
![]() Las Vegas 2-791% +3½ -114Caesars |
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