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Nov 16, 2025 1:00 PM EST
Week 11
BUF
-5½ (-110)o47½ (-110)
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Tampa Bay Buccaneers vs Buffalo Bills Picks
Updated:Nov 13, 2025 1:25 AM EST
The upcoming NFL clash on November 16, 2025, between the Tampa Bay Buccaneers and Buffalo Bills at Highmark Stadium in Orchard Park, NY, promises an exciting Sunday football showdown. Broadcasted on CBS, this game offers bettors valuable insights and expert picks to leverage for smart wagering decisions.
Our prediction model favors the Buffalo Bills with a predicted score of 26 to 22 over the Buccaneers. The recommended best bet is Buffalo Bills -5.5 on the point spread, backed by a 45.7% cover percentage and an EV of -6.7%. Additionally, the under 48.5 total points market shows a slight edge with a 52.7% hit rate and a positive EV of 0.3%, suggesting a game that might stay under the total points line.
In recent games, our NFL predictions have been solid, especially in the under totals market, where we've seen a profitable hit rate in the last 10 games. These statistics can help bettors make informed decisions by focusing on markets with high expected value and good cover percentages. For more detailed NFL picks and expert betting tips, visit our NFL picks page.
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UPCOMING GAME PREDICTION
Spread
Money
Total
TBSpread
CONSENSUS LINE
+5½ (-112)
PROJECTION
TB (22) - BUF (25)
COVER PROBABILITY
EXPECTED VALUE
+1.0%
BET RATING
SEASON COVER %
5/9
56%
EXCLUSIVE BOOSTS
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NFLWeek 11
 New England 8-225% -12½ -118FanDuel | |||||||
 Miami 3-767% -2½ -115Bet365 | |||||||
 N.Y. Giants 2-864% +7 -104FanDuel | |||||||
 Buffalo 6-359% -5½ -110Bet365 | |||||||
 Pittsburgh 5-465% -5½ -110Bet365 | |||||||
 Tennessee 1-878% +7 -117SugarHouse | |||||||
 Minnesota 4-529% -2½ -115Caesars | |||||||
 Atlanta 3-620% -3½ -105Bet365 | |||||||
 Jacksonville 5-446% +3 -114BetRivers | |||||||
 L.A. Rams 7-254% -3 -109BetRivers | |||||||
 Arizona 3-675% +3 -102Caesars | |||||||
 Cleveland 2-785% +8 -117SugarHouse | |||||||
 Denver 8-270% +4 -114BetRivers | |||||||
 Philadelphia 7-273% -2½ -114FanDuel | |||||||
 Las Vegas 2-791% +3½ -114Caesars |
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