Tampa Bay Buccaneers vs Buffalo Bills Game Props

The upcoming Sunday football clash on November 16, 2025, between the Tampa Bay Buccaneers and Buffalo Bills at Highmark Stadium in Orchard Park, NY, is set to be an exciting NFL regular season Week 11 game. Broadcast live on CBS, this game offers plenty of opportunities for savvy bettors to explore game props and prop bets.

The Buffalo Bills bring a strong pass offense that will test the Tampa Bay Buccaneers' pass defense, while Tampa Bay's run offense will face a tough run defense from Buffalo. The Buccaneers' pass protection will be critical against Buffalo's aggressive pass rush, shaping the dynamics of the game and impacting key prop bets like touchdowns and field goals. These matchups create intriguing game projections that bettors can leverage.

Our analysis shows that the player prop market, particularly the "Player to score first touchdown," has a high EV and hit rate, making it a smart bet option. For example, James Cook III is favored with a strong hit rate and positive EV, which aligns with our recent success in prop bets over the last 10 games, where our projections have consistently outperformed the market.

With the pace of play expected to be brisk, totals and team props should also be closely watched. Our projections have been profitable, especially in markets related to touchdowns and field goals, providing bettors with an edge. To dive deeper into player performance and refine your betting strategy, check out our detailed NFL player props and league picks. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.