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The upcoming NFL matchup on November 16, 2025, between the Buffalo Bills and Tampa Bay Buccaneers at Highmark Stadium in Orchard Park, NY, is set to be an intriguing Sunday football game. The Buffalo Bills will enjoy the home advantage, playing in familiar conditions at Highmark Stadium. Tampa Bay Buccaneers will face the challenge of playing away in potentially adverse weather conditions, which could impact their performance.
This game is forecasted to experience rain and partially cloudy skies with temperatures hovering around 39°F, but it will feel closer to 31°F due to the wind chill. The wind blowing from the west at approximately 12-13 mph could affect passing and kicking games, making weather a critical factor to consider in your betting strategy. The Buccaneers have struggled in cold and wet conditions in past seasons, while the Bills have demonstrated resilience in similar weather, which could give them an edge.
Highmark Stadium is an outdoor venue, so the weather will directly influence the gameplay. Rain often leads to a more ground-focused game plan, reducing passing efficiency, and could increase the likelihood of turnovers. Given these conditions, expect a tough, gritty battle with the Bills leveraging their home field and weather familiarity. The game will be broadcast on CBS, allowing fans and bettors to watch the action live.
For bettors looking to make an informed wager, understanding these weather conditions is essential. The best odds available today for Buffalo are u218 -110 at SugarHouse and for Tampa Bay u218 -110 at SugarHouse. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. For more detailed weather insights, visit our NFL weather page to help guide your bets.
New England 8-225% -12½ -118FanDuel | |||||||
Miami 3-767% -2½ -115Bet365 | |||||||
![]() N.Y. Giants 2-864% +7 -104FanDuel | |||||||
Buffalo 6-359% -5½ -110Bet365 | |||||||
![]() Pittsburgh 5-465% -5½ -110Bet365 | |||||||
![]() Tennessee 1-878% +7 -117SugarHouse | |||||||
Minnesota 4-529% -2½ -115Caesars | |||||||
![]() Atlanta 3-620% -3½ -105Bet365 | |||||||
Jacksonville 5-446% +3 -114BetRivers | |||||||
![]() L.A. Rams 7-254% -3 -109BetRivers | |||||||
Arizona 3-675% +3 -102Caesars | |||||||
Cleveland 2-785% +8 -117SugarHouse | |||||||
Denver 8-270% +4 -114BetRivers | |||||||
Philadelphia 7-273% -2½ -114FanDuel | |||||||
![]() Las Vegas 2-791% +3½ -114Caesars |
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