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The upcoming NFL showdown on November 16, 2025, between the Detroit Lions and Philadelphia Eagles at Lincoln Financial Field in Philadelphia, PA, promises to be a thrilling Sunday night football event. Both teams face significant challenges with numerous key injuries impacting their lineups.
The Philadelphia Eagles are dealing with several injuries, notably to core players like long snapper Charley Hughlett who recently underwent successful abdominal surgery and is expected to return in a couple of months. Cornerback Jaire Alexander is questionable with a knee injury and is contemplating retirement, which could affect the Eagles' defensive strategy. Other significant absences include outside linebackers Ogbo Okoronkwo and Azeez Ojulari, safety Marcus Epps, and wide receiver Johnny Wilson, all placed on injured reserve with varying return dates. These injuries could impact Philadelphia's depth and performance on both sides of the ball.
On the Detroit Lions side, the injury list includes defensive lineman Pat O'Connor who is questionable with a knee injury, linebacker Zach Cunningham on injured reserve with a hamstring strain, and defensive end Marcus Davenport on injured reserve with a chest injury. Several other players such as tackle Jamarco Jones, linebacker Ezekiel Turner, and cornerbacks D.J. Reed and Khalil Dorsey are also sidelined. These injuries could limit the Lions' defensive capabilities and affect their game plan.
Understanding these player injuries and statuses is crucial for bettors looking to make informed wagers on this high-stakes NFL game. The injury report reveals vulnerabilities and potential areas for advantage, which can influence betting odds and outcomes. Tune in to NBC and NBC Peacock for live coverage and insights.
For a comprehensive view of all player injuries across the league, visit our NFL injury report page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook to profit from the edge.
New England 8-225% -12½ -118FanDuel | |||||||
Miami 3-767% -2½ -115Bet365 | |||||||
![]() N.Y. Giants 2-864% +7 -104FanDuel | |||||||
Buffalo 6-359% -5½ -110Bet365 | |||||||
![]() Pittsburgh 5-465% -5½ -110Bet365 | |||||||
![]() Tennessee 1-878% +7 -117SugarHouse | |||||||
Minnesota 4-529% -2½ -115Caesars | |||||||
![]() Atlanta 3-620% -3½ -105Bet365 | |||||||
Jacksonville 5-446% +3 -114BetRivers | |||||||
![]() L.A. Rams 7-254% -3 -109BetRivers | |||||||
Arizona 3-675% +3 -102Caesars | |||||||
Cleveland 2-785% +8 -117SugarHouse | |||||||
Denver 8-270% +4 -114BetRivers | |||||||
Philadelphia 7-273% -2½ -114FanDuel | |||||||
![]() Las Vegas 2-791% +3½ -114Caesars |
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