Monday night’s NFL odds feature the San Francisco 49ers installed as traveling favorites over the plummeting Indianapolis Colts. In this Monday night showdown, we spy a sharp side and a value-laden player prop in our Monday night NFL picks.
Last week, the 49ers offense was clicking when Brock Purdy put up 295 passing yards and three touchdowns to lead San Francisco to a 37-24 win over the Titans. Ricky Pearsall led all receivers with 96 yards, while Jauan Jennings caught a pair of touchdown passes. The Niners are now 10-4 straight up and 9-5 against the number.
Indianapolis has been in the midst of a shame spiral recently after sprinting out of the gates to start the season. The Colts have lost four straight, but to be fair, their schedule has not been easy, with losses to the Chiefs, Texans, Jaguars, and last week against the Seahawks.
Indianapolis’ quarterback depth is so shallow, they have had to lure veteran Phillip Rivers out of retirement. The 44-year-old went 18-of-27 for 120 yards with one TD strike and one pick in last week’s 18-16 loss to Seattle.
Let’s explore this MNF matchup and find out where the best value lies.
Best Bets for San Francisco 49ers vs. Indianapolis Colts
Our best bets for Monday night are focused on this interconference clash between the 49ers and the Colts. The 49ers’ defense seemed to be sleepwalking against Tennessee’s rookie quarterback, Cam Ward, and allowed big chunks of yards at a time. San Francisco won the game by a comfortable margin due only to its prolific offense, but the defense will have to buckle down on Monday night against the Colts.
The Colts have had a rough schedule down the stretch, and they have not fared well against the mettle of the league, dropping five of their last six games, with their only victory coming against the underwhelming Atlanta Falcons.
These teams have not faced each other since 2021, when the Colts rang up a 30-18 victory. But that is ancient history, and we see two teams going in opposite directions as the season winds down.
Monday Night Odds (Colts +6)
Early in the week, the oddsmakers installed the 49ers as 5 ½ point home favorites; however, the NFL odds have drifted north to as high as San Francisco -6 ½ at some of the best online sportsbooks.
Crossing into or through an important number like six is significant, and that is precisely what has happened here. This could be a case of public money moving the number, but as much as I like to fade the sheeple, they are not always wrong.
With that said, we noted Caesars has returned to -5 ½ while most of the others have not. Let’s not look a gift horse in the mouth and grab it!
Monday Night Picks (49ers -5½)
According to the OddsTrader gaming model, the 49ers are predicted to defeat the Colts, 25-20, which means all those underdog bettors will eke out an ATS cover. Well, the algorithm is not always accurate, and I am banking on it.
While Phillip Rivers’ eagerness to suit up in an NFL game after being out of the business for five years was impressive, his ability to deliver was only marginal. This is not the Phillip Rivers of old; this is Old Man Rivers, and he will get picked apart by defenses that now have game tape on him.
The Colts only averaged 3.7 yards per play last week against Seattle, and the 49ers will be able to stop Jonathan Taylor because they can play close to the line of scrimmage, as they won’t have to worry about the pass from OMR (Old Man Rivers).
As far as the San Francisco offense is concerned, Brock Purdy will have a field day picking apart this weakened and injured Colts’ secondary. It’s likely we won’t see much of the Niners’ rushing attack, as they will want to avoid the returning DeForest Buckner, but passes over the middle and deep will be successful.
Once the Colts get down by double-digits, there will be no way of rallying with Rivers throwing dinks and dunks. The NFL odds may have gone up on the 49ers in most shops, but Caesars is back to -5 and a hook.
Let’s lay it and like it on the road chalk.
Expert Pick: 49ers -5 ½ (-114) at Caesars
49ers’ Brock Purdy (Over 1½ Passing Touchdowns)
If we take a look at the OddsTrader player prop page, we can see that there are plenty of opportunities, but after reviewing the 49ers vs. Colts player props, we will focus our attention on San Francisco quarterback Brock Purdy.
Purdy has gotten healthier by the week, and it shows in his performance. Last week, he tossed for 295 yards and three touchdowns against the Titans. This Colts’ defense is hobbling, and it wouldn’t surprise me if Purdy replicated those gaudy numbers this week.
Expert Pick: Purdy Over 1.5 Passing Touchdowns (-147) at BetMGM
Place Your MNF Bets & How to Bet Smart This Week
The lines on my Monday night NFL picks, posted today for San Francisco vs. Indianapolis, and the Brock Purdy player prop will not remain stagnant forever. Odds, point spreads, totals, and player props are dynamic, which means the moneylines and point spreads you see here may not be around by gametime.
Therefore, it is important that you get the sharpest line available, and the only way to do that is to get down immediately on the games and make sure you have an active account.
That’s right, make certain your account is funded, and perhaps get accounts at two or more sportsbooks so you can compare the numbers. Make sure to get down at a place you trust and at the best lines or odds available.
While you’re at it, make sure to download the free-to-use OddsTrader App available for iOS and Android phones, for odds, picks, and props anywhere at any time! Speaking of which, you can always check out all the NFL odds on OddsTrader.
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*The line and/or odds referenced in this article might have changed since the content was published. For the latest information on line movements, visit OddsTrader’s free betting odds tool.