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NFL Week 1 Odds: Latest NFL Spreads, Totals & Best Lines Available

Patrick Mahomes Kansas City Chiefs NFL player
Patrick Mahomes 15 of the Kansas City Chiefs throws a pass against the Philadelphia Eagles during the first half in Super Bowl LVII at State Farm Stadium on February 12 2023 Gregory ShamusGetty ImagesAFP

The 2023 NFL regular season is set to kick off with a bang, as the Super Bowl champions Kansas City Chiefs take on the Detroit Lions on September 7. Last season, both teams boasted impressive offenses, and this matchup promises to be a high-scoring affair even with the Travis Kelce injury news.

On Tuesday afternoon, the line in the Lions-Chiefs game dropped from -6.5 to as low as -4.5 (depending on where you shop) after Kelce was scratched from the game due to a hyperextended knee.

Other notable matchups in Week 1 include the San Francisco 49ers facing off against the competitive Pittsburgh Steelers, as the Niners have doubts surrounding their quarterback position. Meanwhile, the Dallas Cowboys take on the New York Giants on Sunday Night Football. 

However, the most talked-about game is likely to be Aaron Rodgers’ debut as a member of the New York Jets on Monday Night Football against Josh Allen and the Buffalo Bills in what will be a matchup between two of the favorites to win the MVP.


NFL Week 1 Odds

Below, you can find the complete list of NFL Week 1 odds. Remember to bookmark this page and check back regularly, as we’ll be updating the odds throughout the off-season

MatchupDateTimeSpreadOver/Under
Lions vs. ChiefsThursday, September 0708:20 PM ETChiefs -4.5 (-110)52.5
Titans vs. SaintsSunday, September 1001:00 PM ETSaints -3.5 (-110)39.5
Jaguars vs. ColtsSunday, September 1001:00 PM ETJaguars -5 (-110)45.5
Buccaneers vs. VikingsSunday, September 1001:00 PM ETVikings -6 (-110)45
Cardinals vs. CommandersSunday, September 1001:00 PM ETCommanders -7 (-110)38
49ers vs. SteelersSunday, September 1001:00 PM ET49ers -2 (-110)41
Bengals vs. BrownsSunday, September 1001:00 PM ETBengals -2.5 (-110)47.5
Panthers vs. FalconsSunday, September 1001:00 PM ETFalcons -3.5 (-110)39.5
Texans vs. RavensSunday, September 1001:00 PM ETRavens -10 (-110)43.5
Packers vs. BearsSunday, September 1004:25 PM ETBears -1 (-110)42.5
Eagles vs. PatriotsSunday, September 1004:25 PM ETEagles -4 (-110)45
Rams vs. SeahawksSunday, September 1004:25 PM ETSeahawks -5 (-110)46
Dolphins vs. ChargersSunday, September 1004:25 PM ETChargers -3 (-110)51
Raiders vs. BroncosSunday, September 1004:25 PM ETBroncos -3.5 (-110)44
Cowboys vs. GiantsSunday, September 1008:20 PM ETCowboys -3.5 (+100)46.5
Bills vs. JetsMonday, September 1108:15 PM ETBills -2.5 (-110)46.5

*Odds via Caesars Sportsbook (check our Caesars Sportsbook Review) as of September 6, 2023.


Best NFL Week 1 Spread Available

Matchup Current Best Spread Available
Lions vs. ChiefsChiefs -4.5 (-110) at Caesars Sportsbook
Titans vs. SaintsSaints -3.5 (-110) at Caesars Sportsbook
Jaguars vs. ColtsJaguars -5 (-110) at Caesars Sportsbook
Buccaneers vs. VikingsVikings -6 (-110) at BetRivers
Cardinals vs. CommandersCommanders -7 (-115) at Caesars Sportsbook
49ers vs. Steelers49ers -2 (-110) at Caesars Sportsbook
Bengals vs. BrownsBengals -2.5 (-110) at Caesars Sportsbook
Panthers vs. FalconsFalcons -3.5 (-110) at Caesars Sportsbook
Texans vs. RavensRavens -10 (-110) at BetRivers
Packers vs. BearsBears -1 (-110) at Caesars Sportsbook
Eagles vs. PatriotsEagles -4 (-110) at Caesars Sportsbook
Rams vs. SeahawksSeahawks -5 (-110) at Caesars Sportsbook
Dolphins vs. ChargersChargers -3 (-110) at Caesars Sportsbook
Raiders vs. BroncosBroncos -3.5 (-106) at Caesars Sportsbook
Cowboys vs. GiantsCowboys -3.5 (+100) at Caesars Sportsbook
Bills vs. JetsBills -2.5 (-110) at Caesars Sportsbook

More Weekly NFL Odds Previews

Eager to explore the upcoming NFL schedule for the most recent odds or curious about the odds of a game that has already taken place? Check out our odds preview covering all 18 weeks of the NFL regular season!


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