Our college football picks for Week 12 feature three of the most important matchups on the Saturday NCAAF slate. As we review the NCAAF odds at all the best US-licensed sportsbooks featured right here at OddsTrader, we will lock in like a laser beam on the 3:30 PM ET matchup between SEC rivals No. 12 Oklahoma and No. 4 Alabama.
After that midafternoon clash, we will watch another pivotal SEC matchup featuring unranked Florida traveling to Oxford to take on No. 6 Ole Miss in a 7:00 PM ET battle. The final leg of what we believe will be a winning NCAAF trifecta is perhaps the most compelling SEC contest between No. 11 Texas and No. 5 Georgia at 7:30 PM ET.
Let’s analyze these three SEC showdowns in our college football predictions in Week 12.
NCAAF Picks Week 12 At-A-Glance
We have done all the homework and the research culminating in our college football picks for Week 12, but now it is time to go shopping for the sharpest lines available at the best US-licensed online sportsbooks right here at OddsTrader.
Let’s start with the Oklahoma vs. Alabama matchup and determine the best value for this week.
Oklahoma Sooners vs. Alabama Crimson Tide (-7)
Saturday, November 15, 2025 – 3:30 PM EST
If you don’t think the Crimson Tide have circled this game at the beginning of the season, then think again. Oklahoma delivered a good old-fashioned beatdown last year in a 23-3 victory over Bama as 13½ point home hounds. But this is a new year, and Alabama has rebounded from a shocking Week 1 loss to Florida State by reeling off eight consecutive wins and covering the number in seven of those eight contests.
Last week was more of the same as the Tide’s defense came to play, limiting LSU to just nine points in a 20-9 Alabama win and covering as 9½ point home chalk. And now the Tide will suit up against an Oklahoma offense that is not nearly as electric as we have seen in the past. The Sooners are averaging a pedestrian 28.9 points per game (63rd), while Bama’s defense is ranked 15th in the nation, holding the opposition to just 17.2 points per game.
The bottom line in this one is that whatever Oklahoma does on offense, Bama does it much better on defense. The one caveat to this bet is that the Tide will not be able to run effectively against the Sooners, but they will be able to pass on them.
Bama averages over 291 passing yards per game, ranked 15th in that category, and I believe that will be all they’ll need to win this one by double digits because I don’t see the Sooners putting any crooked numbers on the scoreboard.
Let’s back the Tide and watch them roll!
Expert Pick: Alabama -7 (-110) at Caesars
Florida Gators vs. Ole Miss Rebels (-16 ½)
Saturday, November 15, 2025 – 7:00 PM EST
The Gators have won and covered their last three meetings against Ole Miss, including last season’s 27-17 victory as 13-point home underdogs. But this season has been a disappointing one for Florida, as they check in with a 3-6 straight-up and ATS mark.
What makes it worse for them as they head to Ole Miss is that they are winless on the road. However, we don’t need the Gators to win; we just need them to cover what I believe are too many points. Now, I wish we were getting an extra hook to make it an even 17, but 16½ points here will get the job done.
Ole Miss has a decent, albeit unspectacular, defense that will be facing an unspectacular Florida offense. The public will be laying the lumber on Ole Miss at any line, and the oddsmakers know this. Florida has an excellent run-stop unit, which means Ole Miss will go to the air early and often. This will make their offense predictable, and that will be good news for a serviceable Florida pass defense. They will be able to anticipate the pass and could cause turnovers because of it.
Let’s grab the points and cash a ticket with the live road dog.
Expert Pick: Florida +16½ (-120) at Caesars
Texas vs. Georgia (-6 ½)
Saturday, November 15, 2025 – 7:30 PM EST
This is the final leg of our three SEC college football picks, and it just may be the most compelling matchup of them all. Texas quarterback Arch Manning was a preseason Heisman Trophy favorite, but his stock has plummeted with a few poor performances.
However, Manning has rebounded lately, as evidenced by a stellar three-touchdown performance and 328 passing yards in his last game, a 34-31 win over No. 9 Vanderbilt. We should also note that the Longhorns are coming off a bye, which means they will be well-rested as they invade Athens, Georgia.
I am not taking anything away from the Bulldogs. They are an excellent team, but they barely squeaked by Florida a few weeks ago, and they will be facing a fresh Texas squad whose pedigreed quarterback is starting to feel it. There’s nothing Arch Manning would want more than to lift his profile with a win over Georgia. And he just might get it!
Expert Pick: Texas +6½ (-110) at BetMGM
How to Bet Smart This Week
My college football picks Week 12 for Oklahoma vs. Alabama, Florida vs. Ole Miss, and Texas vs. Georgia will not remain stagnant forever. Odds, point spreads, and totals are dynamic, which means the moneylines and point spreads you see here may not be around by gametime.
Therefore, it is important that you get the sharpest line available, and the only way to do that is to get down immediately on the games and make sure you have an active account.
That’s right, make certain your account is funded, and perhaps get accounts at two or more sportsbooks so you can compare the numbers. Make sure to get down at a place you trust and at the best lines or odds available.
While you’re at it, make sure to download the free-to-use OddsTrader App available for iOS and Android phones for odds, picks, and props anywhere at any time! Speaking of which, you can always check out all the NCAAF picks for Week 12 on OddsTrader.
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