Thanksgiving means several days of high-profile football games, and the live college football odds have some huge games lined up for the weekend.
For the college football odds Week 14, we are looking at the early lines for some of the marquee games you’ll want to bet and watch this weekend as teams are making their last stand before the college football playoffs.
NCAAF Odds Week 14 At-a-Glance
For this week’s college football odds, we are breaking down two of the most anticipated games with the last big challengers to end perfect season bids. On Friday, it’s No. 3 Texas A&M on the road against Arch Manning and No. 17, then Saturday has the big rivalry between No. 1 Ohio State and No. 18 Michigan. We’ll see if Ohio State and Texas A&M can both win on the road to get to 12-0.
Texas A&M Aggies vs. Texas Longhorns (+2.5)
Friday, November 28, 2025 – 07:30 PM ET
Texas was thought to be a preseason favorite for the national championship behind young Heisman Trophy favorite Arch Manning, while Texas A&M was ranked just inside the top 20 with modest championship odds.
Now, going into the Week 14 college football odds, the Aggies are still undefeated (11-0) thanks to that 30-3 comeback win over South Carolina, and they eye a big road win behind quarterback Marcel Reed, a likely Heisman finalist, against a quality Texas defense.
Meanwhile, Manning and the Longhorns (8-3) are just trying to end the regular season on a high note with a win here, which would be their 3rd win against a top 10 team this season after wins over No. 6 Oklahoma and No. 9 Vanderbilt. Manning has started putting up 300-yard passing games down the stretch, looking more like the passer experts predicted he’d be.
However, the Aggies (5-6 ATS) and Longhorns (3-8 ATS) both have losing spread records and haven’t always lived up to expectations in games this year.
Texas opened as a 10.5-point favorite months ago for this matchup, but it’s the undefeated Aggies who come in as a 2.5-point road favorite while the total (51.5) has been consistent. You can track this week’s line movement at this odds widget below:
Ohio State Buckeyes vs. Michigan Wolverines (+10)
Saturday, November 29, 2025 – 12:00 PM ET
There’s a high noon showdown known as “The Game” this Saturday as arguably college football’s greatest rivalry resumes in the Big Ten between No. 1 Ohio State (11-0) and No. 18 Michigan (9-2).
The only thing standing in the way of an undefeated regular season and top seed for the defending champs is their bitter rival, who has an upset in mind.
Michigan has won 4 in a row (2021-24) in this rivalry, including a 13-10 upset last year in Ohio State without coach Jim Harbaugh (Chargers). That’s what makes this so intriguing, as Michigan has played better football in 2025, gets home-field advantage this time, and the Wolverines dominate the running game.
Meanwhile, Ohio State has a lot of statistics on par with last year’s championship season, including the No. 1 scoring defense in the nation. But it played the 3rd-toughest strength of schedule last year compared to the No. 52 schedule this year in a down season for the Big Ten Conference.
Julian Sayin has put up some incredible passing numbers (79.4% completions, 27 touchdowns, 4 interceptions). However, he hasn’t done it against the toughest competition, and he has rarely faced any adversity this year.
In fact, Ohio State opened as a 5.5-point favorite, and the line has moved to 10 in their favor because of how dominant they’ve been (9-1-1 ATS too).
Ohio State has yet to allow more than 16 points in any game, but we did see Texas push them in a 14-7 game to start the year. We’ll see if the rivalry juices can kick in before a raucous Michigan crowd that will be dying for this upset to happen to run their streak to 5 straight wins over the Buckeyes and create some chaos for the playoffs.
Be sure to follow this week’s college football odds for this matchup in the odds widget:
What We’ve Covered and Next Steps
We’ve looked through the NCAAF odds Week 14 for the best matchups with spreads that are still enticing for some road underdogs in huge games against undefeated teams.
Our most anticipated game is the big one on Saturday between No. 1 Ohio State and Michigan as the Buckeyes try to end a 4-game losing streak to the Wolverines. But we also recommend betting on Friday’s showdown in Texas between the Aggies and Longhorns in the SEC.
Timing is everything in sports betting. By signing up for top-rated sportsbooks, you can find competitive odds for matchups like the ones above, or other college football game picks this week.
You should check out the free OddsTrader app to do your price shopping and make sure you’re getting the best lines and odds available for your top NCAAF picks.
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*The line and/or odds referenced in this article might have changed since the content was published. For the latest information on line movements, visit OddsTrader’s free betting odds tool.