We can decide which bets we should place by examining the live college football odds.
By checking out the live college football odds week 13, we can see that a lot of exciting games will be taking place that we’ll want to have action on. High-profile teams will be competing in battles that have critical playoff expectations.
To gain a clear sense of how these games will play out, we should recognize and track the movement that this week’s college football odds will see after being released.
NCAAF Odds Week 13 At-a-Glance
In this article, I will focus on breaking down the college football betting lines for two highly anticipated games, USC vs. Oregon and Pittsburgh vs. Georgia Tech. All four of these teams might be worth knowing come playoff time, which is precisely why they are worth discussing now.
USC Trojans vs. Oregon Ducks (-9.5)
Saturday, November 22, 2025 – 03:30 PM ET
This game features two teams that could both make the playoffs. However, it is also possible that the team that wins this game will have effectively excluded the loser from making the playoffs.
This game will, therefore, see maximal motivation from the athletes playing in it.
Oregon’s athletes will hope to be healthier this week. Despite missing action, Dakorien Moore is still Oregon’s leading wide receiver. He missed last week’s game against Minnesota due to his knee injury, as did fellow starting wide receiver Gary Bryant Jr. due to his ankle injury.
Their status is worth monitoring, as they would be useful to Oregon’s endeavor to keep pace with USC’s high-powered offense, which ranks eighth in points per game.
That being said, USC is coming off a physical affair against a tough Iowa team in which multiple starting Trojans sustained injuries. Elijah Paige, starting left tackle, and both starting safeties were among those to exit the game.
Oregon’s quarterback would do a vastly better job than Iowa’s at exploiting USC’s secondary if Kamari Ramsey or Bishop Fitzgerald remain hurt.
Oregon opened as a 13.5-point favorite before the spread was bet down four points. Player health will likely dictate further line movement. Check out our fuller matchup preview. See the odds widget to track the line movement.
Pittsburgh Panthers vs. Georgia Tech Yellow Jackets
Saturday, November 22, 2025 – 07:00 PM ET
Both Pittsburgh and Georgia Tech will be highly motivated to win due to the implications that the result of their game will have for their ability to make the ACC Championship Game.
A loss to Georgia Tech knocks out the Panthers. But if they win and then beat Miami in the following week, then they are likely in. If Georgia Tech wins, then, in addition to making the ACC Championship Game, they could make the playoffs.
Expect a much more competitive effort from Pittsburgh this week.
The Panthers are entirely focused on their remaining games, so they will be maximally motivated. They might, however, miss valuable running back Desmond Reid, who had to be carried off the field last week. Pittsburgh, though, has the ninth-ranked rush defense.
So, a Georgia Tech offense that relies heavily on running the ball could be in even more trouble than Pittsburgh’s offense.
Georgia Tech opened as a 2.5-point favorite and remains a 2.5-point favorite. I don’t foresee much line movement, if any. Look at our fuller matchup preview. Scan our odds widget for the current lines.
What We’ve Covered and Next Steps
In this article, I scanned the NCAAF odds week 13 before discussing the most exciting upcoming games.
It will be intriguing to see high-profile Oregon and USC, with their prolific offenses, compete, but you shouldn’t miss out on the competitive high-stakes battle between Pittsburgh and Georgia Tech.
Definitely monitor the injury report for both games before placing your bets.
Timing is everything in sports betting, which means that you want to wager before the line moves in your favor at the top-rated sportsbooks. Download the free-to-use OddsTrader App available for iOS and Android phones for odds, picks, and props anywhere and any time.
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*The line and/or odds referenced in this article might have changed since the content was published. For the latest information on line movements, visit OddsTrader’s free betting odds tool.