NFL Week 2 Odds: NFL Spreads, Totals, Moneylines, etc.

Justin Herbert #10 of the Los Angeles Chargers. Chris Unger/Getty Images/AFP

The 2022 NFL season is almost here and Week 2 is full of very intriguing games. Below you can check out the latest odds for all Week 2 clashes.

NFL Week 2 will bring a lot of drama, as all 32 teams will be in action. The game of the week takes place on Thursday Night Football, with the Los Angeles Chargers visiting the Kansas City Chiefs in a battle of very talented teams looking to go far this season. 

Other can’t-miss games include the Cowboys visiting the Bengals on Sunday afternoon and Titans facing the Bills on Monday Night Football in what could be a playoff preview.

Here is the full slate of games and the latest NFL Week 2 odds

NFL Week 2 Odds

These are the NFL odds for Week 2, headlined by Patrick Mahomes and the Chiefs as 3-point home favorites against Justin Herbert and the Chargers.

MatchupTimeSpreadOver/Under
Chargers vs. ChiefsThursday, September 15, 2022 – 08:15 PM EST at GEHA Field at Arrowhead StadiumChiefs -353
Panthers vs. GiantsSunday, September 18, 2022 – 01:00 PM EST at MetLife StadiumGiants -142.5
Dolphins vs. RavensSunday, September 18, 2022 – 01:00 PM EST at M&T Bank StadiumRavens -446
Patriots vs. SteelersSunday, September 18, 2022 – 01:00 PM EST at Acrisure StadiumPatriots -1.542.5
Jets vs. BrownsSunday, September 18, 2022 – 01:00 PM EST at FirstEnergy StadiumBrowns -643
Commanders vs. Lions     Sunday, September 18, 2022 – 01:00 PM EST at Ford Field  Commanders -144.5
Colts vs. JaguarsSunday, September 18, 2022 – 01:00 PM EST at TIAA Bank FieldColts -4.545.5
Buccaneers vs. SaintsSunday, September 18, 2022 – 01:00 PM EST at Caesars SuperdomeBuccaneers -3.547
Falcons vs. Rams   Sunday, September 18, 2022 – 04:05 PM EST at SoFi StadiumRams -1349.5
Seahawks vs. 49ersSunday, September 18, 2022 – 04:05 PM EST at Levi’s Stadium49ers -8.544
Cardinals vs. RaidersSunday, September 18, 2022 – 04:25 PM EST at Allegiant StadiumRaiders -2.551
Texans vs. BroncosSunday, September 18, 2022 – 04:25 PM EST at Empower Field at Mile HighBroncos -10.542
Bengals vs. CowboysSunday, September 18, 2022 – 04:25 PM EST at AT&T StadiumCowboys -2.550.5
Bears vs. PackersSunday, September 18, 2022 – 08:20 PM EST at Lambeau FieldPackers -1045.5
Titans vs. Bills       Monday, September 19, 2022 – 07:15 PM EST at Highmark StadiumBills -7.5 51 
Vikings vs. EaglesMonday, September 19, 2022 – 08:30 PM EST at Lincoln Financial FieldEagles -2.547.5
Odds courtesy of Caesars Sportsbook as of July 23

MatchupBest Spread Available
Chargers vs. ChiefsChiefs -3 at DraftKings
Panthers vs. GiantsGiants -1 at DraftKings
Dolphins vs. Ravens Ravens -3.5 at SBK
Patriots vs. SteelersPatriots -1 at DraftKings
Jets vs. BrownsBrowns -6 at Caesars Sportsbook
Commanders vs. LionsCommanders -1 at Caesars Sportsbook
Colts vs. JaguarsColts -3.5 at SBK
Buccaneers vs. Saints Buccaneers -3.5 at Caesars Sportsbook
Falcons vs. RamsRams -12.5 at SBK
Seahawks vs. 49ers49ers -7.5 at FanDuel
Cardinals vs. RaidersRaiders -2 at FanDuel
Texans vs. BroncosBroncos -10.5 at Caesars Sportsbook
Bengals vs. CowboysCowboys -1.5 at FanDuel
Bears vs. PackersPackers -8.5 at FanDuel
Titans vs. BillsBills -7 at FanDuel
Vikings vs. EaglesEagles -2 at FanDuel
Odds as of July 23

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