Betting Trends: Detroit Tigers vs Cleveland Guardians

As the Cleveland Guardians prepare to host the Detroit Tigers on September 30, 2025, at Progressive Field in Cleveland, OH, MLB fans are in for a treat. With a strong record at home, the Guardians are set to make a statement in this thrilling matchup. The Tigers, however, are not to be underestimated, boasting an impressive away record. The Guardians' starting pitcher, Gavin Williams, with a 3.06 ERA, will face off against the Tigers' ace, Tarik Skubal, whose 2.212 ERA marks him as a formidable opponent.

The Guardians recently triumphed over the Texas Rangers, while the Tigers had a narrow loss to the Boston Red Sox. With both teams having strong recent performances, this game is set to be a nail-biter. Fans can catch the action on ESPN, and with the Tigers favored at -165 on the moneyline, there's plenty of betting interest.

The Guardians' ATS record is solid, as seen on our MLB standings page. The Tigers, meanwhile, are looking to improve their ATS standing. With the over/under set at 6, bettors should look at the recent head-to-head clashes, where runs have often been at a premium. For those looking to make informed bets, considering the starting pitchers' stats, including strikeout rates and SIERA, could be key. Start your OddsTrader Turbo subscription now for the best insights and place your bet with a U.S. regulated sportsbook.