Clemson Tigers vs Louisville Cardinals Player Props

The upcoming Friday football game on November 14, 2025, features the Louisville Cardinals hosting the Clemson Tigers at L&N Federal Credit Union Stadium in Louisville, KY. This NCAAF regular season Week 12 clash is set to be an exciting matchup for player props enthusiasts and sports bettors alike, airing on ESPN. The game offers a compelling battle between the Cardinals and Tigers, with a key focus on passing yards, rushing yards, and receiving yards that will influence prop bets and player projections.

Louisville's offense will rely heavily on Miller Moss's passing ability, though our player projections suggest an under 246.5 passing yards hit rate of 67.3% with a solid EV of 15.0%. Meanwhile, Keyjuan Brown's receiving yards and receptions present attractive prop bets with high expected value, including an under 2.5 receptions with an 88.6% hit rate and an under 79.5 rushing yards at nearly 70% hit rate. Clemson's offense is led by Cade Klubnik, whose passing yards over 260.5 have a 61.1% hit rate and a 7.6% EV, making it a promising prop bet to consider.

The matchup pits Louisville's pass defense against Clemson's pass offense, along with comparisons of run offense versus run defense and pass protection versus pass rush, all of which will affect player props outcomes. Our player props results from the last 10 games have demonstrated profitable returns, especially in receiving yards markets, making this an excellent opportunity for bettors to capitalize on high-value prop bets.

For detailed player projections and to explore more prop bets in this NCAAF season, check out the NCAAF player props page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.