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The upcoming clash on December 6, 2025, between the Indiana Hoosiers and Ohio State Buckeyes at Lucas Oil Stadium in Indianapolis, IN, is set to be a thrilling Saturday football showdown in the 2025-26 NCAAF season. Indiana Hoosiers come into this game with a strong 12-0 straight-up record and a 7-5 ATS record, showing resilience and consistency. Ohio State Buckeyes boast a 12-0 straight-up record as well, with an impressive 10-1-1 ATS record, especially dominant at home with a 7-0 straight-up and 6-0 ATS home record.
Starting quarterbacks will play a crucial role, with Indiana's QB leading an offense averaging 254 passing yards per game, while Ohio State's QB commands a potent attack averaging 267 passing yards. Defensively, Indiana allows 172 passing yards, while Ohio State is stingier, allowing only 121 passing yards per game. Indiana's run game averages 229 rushing yards, contrasting with Ohio State's 171 rushing yards. Ohio State's defense is tougher against the run, giving up 203 yards per game compared to Indiana's 251 yards allowed.
The point spread is set at Ohio State Buckeyes -4, with a total points line at 47. The Buckeyes' strong pass protection and pass rush, combined with their defensive stats, make them favorites, but Indiana's high-powered rushing offense can keep the game competitive. The recent performances show Indiana's explosive offense with wins like 56-3 over Purdue and 31-7 over Wisconsin, while Ohio State has dominated with wins like 42-9 against Rutgers and 48-10 over UCLA.
For bettors, these betting trends and game insights point towards a competitive game where Ohio State's home advantage and defensive prowess might be the edge. The best odds available today for Indiana are +4 at Caesars and for Ohio State -4 at Caesars. This matchup will be broadcast on FOX, making it accessible for fans nationwide. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
In their last matchup on November 23, 2024, the Ohio State Buckeyes defeated the Indiana Hoosiers 38-15, showcasing their dominance at Ohio Stadium. Check out the Indiana Hoosiers vs Ohio State Buckeyes game details and stats on our last matchup from November 23, 2024.
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