BETTING

2025 MLB Opening Day Computer Picks: Can the Tigers Keep Up with the Dodgers?

It’s Opening Day in the MLB, and the AI Model has us covered! I asked the AI Model for its favorite bets of the night slate. Here’s what it came up with!

And don’t forget to check out our YouTube channel for more MLB betting advice. Today, our expert covered the Brewers vs. Yankees and Braves vs. Padres games!

Picks Summary

  • Tigers-Dodgers Over 6.5 (-140)
  • Cubs ML (+110)
  • Athletics-Mariners Over 7 (-110)

*All odds from Bet365 (check our Bet365 Review)


Detroit Tigers vs. Los Angeles Dodgers

Thursday, March 27, 2025 – 07:10 PM EDT at Dodger Stadium


Our AI Model thinks the Dodgers and Tigers will combine for 10.4 runs in tonight’s showdown. However, the total is currently sitting at just 6.5 at most sportsbooks. The Over has a ton of value in this game.

Tarik Skubal Will Get The Opening Day Start!

The Tigers are giving their left-handed phenom the ball to start opening day. Tarik Skubal struck out 30% of batters and allowed only 4.4% of walks with a .106 ISO and wOBA of .246 last season.

He was absolutely terrific. That said, he’s taking on the Dodgers, who have one of the best lineups in baseball.

The Dodgers’ projected lineup hit a .246 ISO and wOBA of .378 against lefties while striking out below 20% of the time.

Skubal will likely allow a few runs and then give the bullpen the ball in the second portion of the game.

Can We Trust Blake Snell?

Blake Snell sometimes looks like the best pitcher in the MLB. Other times, he doesn’t. Snell struck out 34.7% of batters last season with the Padres. However, he walked 10.5% of batters and allowed nearly 27% of fly balls with almost 38% of hard contact.

The Tigers don’t have the most efficient lineup against lefties, but if they’re patient, they’ll get Snell out of the game early.

The Pick

I like the Over 6.5 despite two phenoms on the mound.

MLB Pick: Over 6.5 (-140) at Bet365


Chicago Cubs vs. Arizona Diamondbacks

Thursday, March 27, 2025 – 10:10 PM EDT at Chase Field


The AI Model believes the Cubs will escape with a 5.3-4.6 win on the road against the Diamondbacks. The Cubs are +110 on the moneyline and are expected to win outright. Back the Cubs tonight.

Justin Steele Will Be Fine?

The Cubs played two games in Japan and had Justin Steele pitch the second game of that series.

Steele finished with an 11.25 ERA and a loss. He didn’t look great against the Dodgers. But he was also pitching against the Los Angeles Dodgers in another country.

That’s not the ideal spot to debut.

Therefore, the Cubs are rolling with Steele again tonight in a little redemption game for himself. Steele added 24.3% of strikeouts and limited teams to a .117 ISO and wOBA of .269 last year. He was a stud and should be able to keep walks down against a Diamondbacks group that walked only 7.5% of the time against lefties last season.

Zac Gallen Had His Ups & Downs

The Diamondbacks will roll with Zac Gallen tonight. Gallen had his ups and downs last season but ultimately still struck out 25.1% of batters.

The main concern was the fact that he allowed 46.7% of hard contact when players made contact. That was super high. He’ll want to keep that number down. But against the Cubs, it’s unlikely.

Chicago’s projected lineup hit 46.1% of hard contact against righties last season. That’s why the Cubs are a live dog tonight.

The Pick

Back the Cubs at +110.

MLB Pick: Cubs ML (+110) at Bet365


Oakland Athletics vs. Seattle Mariners

Thursday, March 27, 2025 – 10:10 PM EDT at T-Mobile Park


The AI Model suggests the Marins and Athletics will combine for 7.5 runs tonight. Meanwhile, the total is currently at 7. Consider the Over in this game as well.

Luis Severino’s First Start With Oakland!

The Oakland Athletics actually spent some money this off-season. They brought in former Mets’ starter, Luis Severino.

Severino only struck out 20.8% of batters last season. He also allowed a .172 ISO and wOBA of .341 to lefties last year.

He’ll have to face Cal Raleigh and Luke Raley, who both destroyed right-handed pitching last season with super high ISO numbers.

Additionally, Oakland’s bullpen is a major question mark. They’ve got Mason Miller, but what about the rest of the group?

Severino won’t last nine innings.

Logan Gilbert Will Start For Seattle

The Mariners will send out former All-Star starter Logan Gilbert. Gilbert gave up a .169 ISO to 359 lefties last season and will battle lefties like Lawrence Butler, JJ Bleday, and Tyler Soderstrom.

All three of these lefties had legitimate success against righties last year.

The Pick

I agree with the AI Model and think the seven is a little too low. Let’s pounce and take the over.

MLB Pick: Over 7 (-110) at Bet365

*21+ Seek help with a gambling addiction at 1-800-Gambler

*The line and/or odds referenced in this article might have changed since the content was published. For the latest information on line movements, visit OddsTrader’s free betting odds tool.

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