We only have two more weeks to craft our college football picks, and then the postseason begins, starting with conference championships, followed by the top dozen teams that will vie for national supremacy in the College Football Playoff.
But before we get too ahead of ourselves, let’s focus our attention on our college football picks Week 13 as we isolate the marquee matchups that will fatten our wallets. This week’s best college football picks include three games, all with ranked opponents playing each other.
We begin with a midafternoon clash between No. 17 USC as they travel to No. 8 Oregon. That will be followed by No. 22 Pittsburgh as they invade No. 16 Georgia Tech in an early evening showdown. The last game of our three-pick trifecta is No. 12 BYU traveling to the Queen City, where they will kick off against No. 25 Cincinnati.
NCAAF Picks Week 13 At-A-Glance
We have shopped for the sharpest odds at the best US-licensed online sportsbooks right here at OddsTrader and have done our research to reveal our college football picks for Week 13.
This week, our best college football picks for Week 13 are as follows:
- Oregon -9 ½
- Pittsburgh +2 ½
- BYU -2 ½
Let’s start with the USC vs. Oregon matchup and determine the best value for this week.
USC Trojans vs. Oregon Ducks (-9 ½)
Saturday, November 22, 2025 – 03:30 PM ET
Oregon has defeated USC in five of its last six meetings, but that doesn’t mean much considering their last battle took place in 2023 and they play each other roughly every three years. It’s a meaningless stat that will be tossed around this week by handicappers looking for something to say.
However, what is important is Oregon’s narrow win on the road over Iowa two weeks ago before stomping Minnesota, 42-13, last week. The key to the Ducks’ success this season is a magnificent pass defense, ranked No. 1 in the nation, while owning one of the best rushing attacks in the nation.
USC comes equipped with the No. 11 passing offense in the nation, which means that Oregon’s pass defense will be put to the test. However, if the Trojans decide to run, they will find that the Ducks’ run-stop unit is more than up to the task.
The Trojans will eventually get desperate to catch up and begin making mistakes and turning the ball over. That’s when we see the Ducks win this one by double digits.
Expert Pick: Oregon -9 ½ (-102) at Caesars
Pittsburgh Panthers vs. Georgia Tech Yellow Jackets (-2.5)
Saturday, November 22, 2025 – 07:00 PM ET
The Pittsburgh Panthers will try to pull a slight upset over their hosts from Georgia Tech. And we believe that a win is in the cards for the Cats, and the oddsmakers have the wrong favorite in this one.
The Panthers watched their five-game winning and covering streak come to an end last week when they stepped way up in class and lost to Notre Dame, 37-15. That was an ideal time for them to take an embarrassing loss because this week they won’t find the sledding nearly as tough with Georgia Tech.
The Panthers own the 15th-ranked passing attack, averaging nearly 288 yards per game, while G-Tech’s pass defense ranks 103rd in the nation, allowing over 243 yards per game. This is why Georgia Tech won’t be able to keep pace with Pittsburgh.
The moneyline on the Panthers is +115 if you’re so inclined, but at least take the points.
Expert Pick: Pittsburgh +2½ (-102) at Caesars
BYU Cougars vs. Cincinnati Bearcats (+2.5)
Saturday, November 22, 2025 – 08:00 PM ET
This Big 12 battle between the Cougars and Bearcats shows the visitors as 2 ½ point favorites, and that’s just fine with us because our spread had BYU as 5-point road chalk. BYU has won and covered the last three meetings against the Bearcats, and this will be their fourth in a row.
The Cougars are a resilient squad, as evidenced by their 44-13 destruction of TCU last week as three-point home chalk after watching their undefeated season vanish the week before, courtesy of a 29-7 loss to No. 6 Texas Tech.
I can’t understand how Cincinnati will stop this vastly superior BYU offense. Yes, the Bearcats have a good offense of their own, but their defense is inept and porous. This could get ugly early, so let’s back the better team at short odds that make this one of our best bets on Saturday’s NCAAF board.
Expert Pick: BYU -2½ (-102) at Caesars
Place Your Week 13 Picks & How to Bet Smart This Week
My college football picks for Week 13, posted today for USC vs. Oregon, Pittsburgh vs. Georgia Tech and BYU vs. Cincinnati will not remain stagnant forever. Odds, point spreads, and totals are dynamic, which means the moneylines and point spreads you see here may not be around by gametime.
Therefore, it is important that you get the sharpest line available, and the only way to do that is to get down immediately on the games and make sure you have an active account.
That’s right, make certain your account is funded, and perhaps get accounts at two or more sportsbooks so you can compare the numbers. Make sure to get down at a place you trust and at the best lines or odds available.
While you’re at it, make sure to download the free-to-use OddsTrader App available for iOS and Android phones for odds, picks, and props anywhere at any time! Speaking of which, you can always check out all the NCAAF picks for Week 13 on OddsTrader.
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