Week 3 kicks off on September 21 with the New York Giants facing the San Francisco 49ers on the West Coast for a second consecutive game out in the West Coast, just four days after their historic comeback against the Arizona Cardinals, in Week 2.
On Sunday, the Indianapolis Colts visit the Baltimore Ravens, bringing back memories of the Colts’ relocation from Baltimore to Indianapolis. The question is if Anthony Richardson will play after self-reporting concussion symptoms during the win against the Texans, last Sunday. The 1 PM slate also offers an interesting matchup between the Broncos and the Miami Dolphins, with Sean Payton trying to avoid an 0-3 start with the Broncos.
Also, you don’t want to miss out on the action of the divisional showdown between the Patriots and the Jets at MetLife Stadium as Bill Belichick looks to keep preying on Zach Wilson.
Finally, the second Monday Night Football doubleheader of the season features the Eagles against the Buccaneers and the Bengals hosting the Rams.
NFL Week 3 Odds
Below is the complete list of NFL Week 3 odds.
| Matchup | Date | Time | Spread | Over/Under |
|---|---|---|---|---|
| Giants vs. 49ers | Thursday, September 21 | 08:15 PM ET | 49ers -10.5 (-110) | 45 |
| Colts vs. Ravens | Sunday, September 23 | 01:00 PM ET | Ravens -7.5 (-110) | 44 |
| Broncos vs. Dolphins | Sunday, September 23 | 01:00 PM ET | Dolphins -6.5 (-110) | 48 |
| Patriots vs. Jets | Sunday, September 23 | 01:00 PM ET | Patriots -3 (-110) | 37 |
| Texans vs. Jaguars | Sunday, September 23 | 01:00 PM ET | Jaguars -9.5 (-110) | 44 |
| Titans vs. Browns | Sunday, September 23 | 01:00 PM ET | Browns -3.5 (-110) | 41.5 |
| Falcons vs. Lions | Sunday, September 23 | 01:00 PM ET | Lions -3.5 (-110) | 45.5 |
| Saints vs. Packers | Sunday, September 23 | 01:00 PM ET | Packers -2 (-110) | 43 |
| Bills vs. Commanders | Sunday, September 23 | 01:00 PM ET | Bills -6.5 (-110) | 44.5 |
| Chargers vs. Vikings | Sunday, September 23 | 04:05 PM ET | Vikings PK (-110) | 54 |
| Panthers vs. Seahawks | Sunday, September 23 | 04:05 PM ET | Seahawks -4.5 (-110) | 42.5 |
| Bears vs. Chiefs | Sunday, September 23 | 04:25 PM ET | Chiefs -13 (-110) | 48 |
| Cowboys vs. Cardinals | Sunday, September 23 | 04:25 PM ET | Cowboys -12.5 (-110) | 43.5 |
| Steelers vs. Raiders | Sunday, September 23 | 08:20 PM ET | Raiders PK (-110) | 44 |
| Eagles vs. Buccaneers | Monday, September 24 | 07:15 PM ET | Eagles -5.5 (-110) | 46 |
| Rams vs. Bengals | Monday, September 24 | 08:15 PM ET | Bengals -2 (-110) | 43.5 |
*Odds via Caesars Sportsbook (check our Caesars Sportsbook Review) as of September 18, 2023.
Best NFL Week 3 Spread Available
| Matchup | Current Best Spread Available |
|---|---|
| Giants vs. 49ers | Giants -10.5 (-110) at Caesars Sportsbook |
| Colts vs. Ravens | Ravens -7.5 (-109) at BetRivers |
| Broncos vs. Dolphins | Dolphins -6.5 (-110) at Caesars Sportsbook |
| Patriots vs. Jets | Patriots -3 (-109) at BetRivers |
| Texans vs. Jaguars | Jaguars -9 (-112) at BetRivers |
| Titans vs. Browns | Browns -3.5 (-110) at Caesars Sportsbook |
| Falcons vs. Lions | Lions -3.5 (-110) at Caesars Sportsbook |
| Saints vs. Packers | Packers -2 (-110) at Caesars Sportsbook |
| Bills vs. Commanders | Bills -6.5 (-110) at Caesars Sportsbook |
| Chargers vs. Vikings | Vikings PK (-110) at Caesars Sportsbook |
| Panthers vs. Seahawks | Panthers -4.5 (-110) at Caesars Sportsbook |
| Bears vs. Chiefs | Chiefs -13 (-110) at Caesars Sportsbook |
| Cowboys vs. Cardinals | Cowboys -11.5 at SBK |
| Steelers vs. Raiders | Raiders PK (-110) at Caesars Sportsbook |
| Eagles vs. Buccaneers | Eagles -5.5 (-110) at Caesars Sportsbook |
| Rams vs. Bengals | Bengals -1.5 (-113) at BetRivers |
More Weekly NFL Odds Previews
Eager to explore the upcoming NFL schedule for the most recent odds or curious about the odds of a game that has already taken place? Check out our odds preview covering all 18 weeks of the NFL regular season!
- Week 1 Odds
- Week 2 Odds
- Week 4 Odds
- Week 5 Odds
- Week 6 Odds
- Week 7 Odds
- Week 8 Odds
- Week 9 Odds
- Week 10 Odds
- Week 11 Odds
- Week 12 Odds
- Week 13 Odds
- Week 14 Odds
- Week 15 Odds
- Week 16 Odds
- Week 17 Odds
- Week 18 Odds
