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The upcoming MLB game on June 22, 2026, features the Arizona Diamondbacks visiting the St. Louis Cardinals at Busch Stadium in St. Louis, MO. Broadcasted on arid, this matchup presents a competitive betting landscape in the league. Our picks favor St. Louis with a predicted score of 4.7 against Arizona's 4.1, suggesting a close game with St. Louis covering the -1.5 spread at a 40.7% probability. Hitters' performance against right-handed pitchers, as both starters are right-handed, favors St. Louis slightly. Our prediction model has been profitable over the last 10 games, with a high EV and hit rate on point spread bets, reinforcing the value in our picks. For more detailed analysis and league-wide picks, see our MLB picks and predictions page.
![]() TORS. Bieber (R) 39-39- -133BetOnline | |||||||
![]() DETC. Mize (R) 34-4441% +108Everygame | |||||||
TBS. McClanahan (L) 43-320% -180BetOnline | |||||||
PITM. Keller (R) 39-3930% +112Everygame | |||||||
MIAS. Alcantara (R) 40-39- -150Everygame | |||||||
WSHZ. Littell (R) 41-3892% +148Everygame | |||||||
CINN. Lodolo (L) 37-4053% +109Bet105 | |||||||
NYMK. Senga (R) 34-4385% -115BetOnline | |||||||
![]() CWSS. Burke (R) 40-3736% +101Everygame | |||||||
![]() MINK. Rojas (L) 38-42100% +155Everygame | |||||||
STLK. Leahy (R) 42-3465% -108BetOnline | |||||||
![]() COLS. Sullivan (L) 31-48100% +145Everygame | |||||||
LAAR. Johnson (R) 32-48- +140Everygame | |||||||
![]() SDG. Canning (R) 40-37- -107Heritage | |||||||
SFR. Ray (L) 31-4680% -116Bet105 | |||||||
NYMS. Manaea (L) 34-43- - |