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The Pittsburgh Pirates and Athletics square off on September 20, 2025, at PNC Park in Pittsburgh, PA. As the MLB season heats up, both teams are eager to make their mark. The Athletics recently edged out the Pirates 4-3 in their last encounter. This game promises an exciting showdown with both teams having a lot to prove. The Athletics have shown prowess against righthanded pitchers, a potential advantage if the Pirates start with a righthanded pitcher. Our picks favor the Athletics with a predicted score of 4.6 to the Pirates' 3.7. The Athletics are predicted to cover the spread at -1.5 with a 44.7% probability, while the Pirates are at +1.5 with a 55.3% probability. With the game airing on SportsNet PT, fans can catch the action live. For more insights and betting tips, check out our MLB picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
MIAJ. Junk (R) 11-1344% -135BetOnline | |||||||
![]() CLET. Bibee (R) 14-1118% -147Bookmaker | |||||||
TBN. Martinez (R) 12-1157% -131Bet105 | |||||||
KCM. Wacha (R) 8-166% -130Everygame | |||||||
LAAJ. Soriano (R) 11-1423% -142BetAnything | |||||||
SEAL. Gilbert (R) 10-1536% -175BetOnline | |||||||
![]() DETC. Mize (R) 12-1285% -128Bet105 | |||||||
WSHZ. Littell (R) 11-1396% +133Bookmaker | |||||||
BOSR. Suarez (L) 9-1479% +126Everygame | |||||||
NYMC. Holmes (R) 7-160% -140Heritage | |||||||
![]() CHCM. Boyd (L) 14-919% -162Bet105 | |||||||
![]() TEXJ. Leiter (R) 12-1150% +102Bookmaker | |||||||
![]() COLT. Sugano (R) 9-1589% +140Everygame | |||||||
![]() AZE. Rodriguez (L) 13-106% -136Heritage | |||||||
SFT. Mahle (R) 10-1392% +186Bookmaker |