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Get ready for an exciting showdown as the Pittsburgh Pirates host the Athletics at PNC Park in Pittsburgh, PA, on September 21, 2025. As we approach this MLB clash, both teams are gearing up for a thrilling game. The Athletics, coming off a recent win, have shown strong performance against righthanded pitchers. Meanwhile, the Pirates, playing on their home turf, are looking to capitalize on their familiarity with the venue. According to our predictions, the Athletics are favored to win with a predicted score of 4-3. With a hit rate of 64.9% for covering the spread, the Athletics are a solid pick. Our previous predictions have been spot on, winning 6 of the last 10 games. Ready to place your bets? Start your OddsTrader Turbo subscription or check out our MLB picks page for more insights. Catch the game live on nbcs-ca for an afternoon of baseball action!
MIAJ. Junk (R) 11-1341% -135BetOnline | |||||||
![]() CLET. Bibee (R) 14-1118% -147Bookmaker | |||||||
TBN. Martinez (R) 12-1159% -133Bet105 | |||||||
KCM. Wacha (R) 8-166% -130Everygame | |||||||
LAAJ. Soriano (R) 11-1423% -142BetAnything | |||||||
SEAL. Gilbert (R) 10-1536% -175BetOnline | |||||||
![]() DETC. Mize (R) 12-1285% -129BetOnline | |||||||
WSHZ. Littell (R) 11-1396% +133Bookmaker | |||||||
BOSR. Suarez (L) 9-1477% +126Everygame | |||||||
NYMC. Holmes (R) 7-160% -140Heritage | |||||||
![]() CHCM. Boyd (L) 14-919% -162Bet105 | |||||||
![]() TEXJ. Leiter (R) 12-1157% +102Bookmaker | |||||||
![]() COLT. Sugano (R) 9-1589% +140Everygame | |||||||
![]() AZE. Rodriguez (L) 13-106% -136Heritage | |||||||
SFT. Mahle (R) 10-1392% +186Bookmaker |