- Run Line
- Money
- Total
- Merged
The MLB regular season game on April 21, 2026, features the Boston Red Sox hosting the N.Y. Yankees at Fenway Park in Boston, MA. Broadcast live on TBS, this matchup presents a close contest with our prediction model slightly favoring the Red Sox to win 5-4, though the Yankees hold a 63.8% probability of covering the -1.5 spread. The starting pitchers' handedness influences hitters' performance, affecting betting tips. Our model's picks have demonstrated strong profitability in recent games, with a high EV point spread market showing a consistent hit rate. For comprehensive MLB betting insights, visit our MLB picks page.
TBC. Legumina (R) 44-3342% -136BetAnything | |||||||
PITB. Chandler (R) 40-4067% +135Everygame | |||||||
SFL. Roupp (R) 33-4658% -117Bookmaker | |||||||
![]() DETT. Melton (R) 34-4665% -104Bookmaker | |||||||
WSHC. Cavalli (R) 41-4067% +155Everygame | |||||||
![]() TORK. Gausman (R) 39-4117% -126Heritage | |||||||
NYMF. Peralta (R) 34-4620% -102Bookmaker | |||||||
BOSC. Early (L) 32-4666% +141BetAnything | |||||||
STLM. McGreevy (R) 42-3611% -129BetOnline |