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The upcoming MLB matchup on April 22, 2026, features the N.Y. Yankees versus the Boston Red Sox at Fenway Park in Boston, MA. Broadcasted on NESN and MLB Network, this game offers valuable picks and betting tips for bettors. Our prediction model forecasts a Yankees win with a projected score of 5.6 to 4.6, favoring the Yankees on the moneyline despite the Red Sox's slight edge in spread coverage probability at 54.97%. Notably, the predicted total runs exceed 7.5, aligning with a 57.3% hit rate and a positive EV of 4.9%. The Yankees' hitters have a 58.7% probability to win against the opposing pitcher, reflecting their strong performance versus right-handed pitchers, which is critical as the starting pitcher details emerge. Our model's American Totals picks have been profitable recently, winning 6 of the last 10 games with a high EV and hit rate, supporting an over 7.5 total in this contest. For comprehensive insights, visit our MLB picks and predictions page.
PITP. Skenes (R) 41-40100% -201BetOnline | |||||||
![]() DETK. Montero (R) 34-47100% -114BetAnything | |||||||
BALT. Rogers (L) 38-44100% -128BetOnline | |||||||
![]() TORP. Corbin (L) 39-4267% +102Everygame | |||||||
NYMUndecided 34-47- +142BetOnline | |||||||
BOSP. Tolle (L) 33-46100% +106Everygame | |||||||
![]() CLEJ. Cantillo (L) 42-39100% -108BetOnline | |||||||
TBN. Martinez (R) 45-33- -131Bookmaker | |||||||
![]() CWSD. Sandlin (R) 41-38- -135MyBookie | |||||||
MILJ. Misiorowski (R) 49-29- -255BetOnline | |||||||
![]() MINT. Bradley (R) 38-440% -157Bet105 | |||||||
STLM. McGreevy (R) 42-3633% -109Bookmaker | |||||||
LAAW. Ureña (R) 34-48100% +112BetOnline | |||||||
![]() SDW. Buehler (R) 42-3750% +135Everygame |