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On September 21, 2025, the Chicago Cubs will face off against the Cincinnati Reds at the Great American Ball Park in Cincinnati, OH. This MLB game promises excitement as both teams vie for supremacy. The Cubs, with their formidable lineup, are set to challenge the Reds on their home turf. Current odds have the Reds as slight favorites at -115, while the Cubs are at -105. The run line is set at -1.5 -110 for the Reds and +1.5 -110 for the Cubs, indicating a closely contested matchup. Bettors should also consider the over/under set at 9.0 with odds of -105 for the over and -115 for the under, offering potential value for those looking to wager on total runs. The game will be broadcast on FDSOH, FDSNOH, and MARQ+. Ready to make informed bets? Explore OddsTrader Turbo for insights or check the latest MLB odds for the game.
MIAJ. Junk (R) 11-1344% -135BetOnline | |||||||
![]() CLET. Bibee (R) 14-1118% -147Bookmaker | |||||||
TBN. Martinez (R) 12-1157% -131Bet105 | |||||||
KCM. Wacha (R) 8-166% -130Everygame | |||||||
LAAJ. Soriano (R) 11-1423% -144BetAnything | |||||||
SEAL. Gilbert (R) 10-1536% -175BetOnline | |||||||
![]() DETC. Mize (R) 12-1285% -128Bet105 | |||||||
WSHZ. Littell (R) 11-1396% +133Everygame | |||||||
BOSR. Suarez (L) 9-1479% +126Everygame | |||||||
NYMC. Holmes (R) 7-160% -140Heritage | |||||||
![]() CHCM. Boyd (L) 14-919% -162Bet105 | |||||||
![]() TEXJ. Leiter (R) 12-1150% +102Bookmaker | |||||||
![]() COLT. Sugano (R) 9-1589% +140Everygame | |||||||
![]() AZE. Rodriguez (L) 13-106% -136Heritage | |||||||
SFT. Mahle (R) 10-1392% +185Bet105 |