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The Cincinnati Reds will face the Chicago Cubs at Wrigley Field in Chicago, IL, on May 5, 2026, with game time at 7:40 PM EDT, broadcasted on Marquee Sports Network. Our picks favor the Cubs with a predicted score of 4.48 to 3.59, although the Reds have a 56.4% probability to cover the +1.5 spread. Both teams' hitters' performance against right-handed pitchers influences gameplay, as the Cubs' starting pitcher is right-handed. Our prediction model has been profitable, with a 59.8% hit rate on 2-way bets in the last 10 games, supporting these betting tips. For detailed MLB insights, visit MLB Picks and Predictions.
TBC. Legumina (R) 44-3344% -135BetAnything | |||||||
PITB. Chandler (R) 40-4071% +135Everygame | |||||||
SFL. Roupp (R) 33-4659% -122JustBet | |||||||
![]() DETT. Melton (R) 34-4667% -104JustBet | |||||||
WSHC. Cavalli (R) 41-4070% +163Bookmaker | |||||||
![]() TORK. Gausman (R) 39-4119% -144Bet105 | |||||||
NYMF. Peralta (R) 34-4618% -102Bookmaker | |||||||
BOSC. Early (L) 32-4670% +145Everygame | |||||||
STLM. McGreevy (R) 42-3612% -129BetOnline |