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FINAL
Feb 27, 2026 3:05 PM EST
CLE 6 vs CHC 8
CHC
-155o11½ (-110)
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Cleveland Guardians vs Chicago Cubs Picks
Updated:Feb 27, 2026 1:13 AM EST
The upcoming Cleveland Guardians vs Chicago Cubs game on February 27, 2026, at Sloan Park in Mesa, AZ, is set to open the MLB season with exciting action. Fans and bettors alike can catch all the live action on the scheduled TV stations. This MLB matchup pits the Cleveland Guardians against the Chicago Cubs, promising a thrilling baseball contest.
Our picks and betting tips highlight the importance of analyzing pitcher matchups for this game. If the starting pitcher is right-handed, consider how both teams’ hitters perform against right-handed pitchers, and similarly for left-handed starters. This insight can help bettors make smart wagering decisions.
Based on recent prediction models, which have been profitable winning 6 out of the last 10 games on American totals, we predict a close contest with a final score of Cleveland Guardians 4, Chicago Cubs 3. We favor the Guardians on the moneyline for this game. The best odds available today for Cleveland are SugarHouse, while Chicago Cubs’ best lines can also be found there.
For comprehensive MLB picks and further expert analysis, be sure to visit our MLB picks page to stay ahead of the game and maximize your betting success.
MLB
Money
Game
- Game
- 1st 5
MLBThu 06/25
 TBC. Legumina (R) 44-3342% -136BetAnything | |||||||
 PITB. Chandler (R) 40-4067% +135Everygame | |||||||
 SFL. Roupp (R) 33-4658% -117Bookmaker | |||||||
 DETT. Melton (R) 34-4665% -104Bookmaker | |||||||
 WSHC. Cavalli (R) 41-4067% +155Everygame | |||||||
 TORK. Gausman (R) 39-4117% -126Heritage | |||||||
 NYMF. Peralta (R) 34-4620% -102Bookmaker | |||||||
 BOSC. Early (L) 32-4666% +145Everygame | |||||||
 STLM. McGreevy (R) 42-3611% -129BetOnline |
RAYS...
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