- Run Line
- Money
- Total
- Merged
The Houston Astros face the Chicago Cubs at Wrigley Field in Chicago, IL, on May 22, 2026, in an MLB regular season game. The game will be broadcast on Apple TV+. Current odds show the Cubs favored on the run line at -1.5 +147, compared to the Astros at +1.5 -167. Opening odds indicated a narrower margin, reflecting a shift favoring the Astros. The total runs line stands at 7 with balanced odds, highlighting the expected scoring environment. These betting lines offer valuable insights for evaluating game dynamics and potential outcomes. For comprehensive MLB odds, visit the MLB odds page.
![]() TORS. Bieber (R) 39-3975% -124Everygame | |||||||
![]() DETC. Mize (R) 34-4445% +101Bet105 | |||||||
TBS. McClanahan (L) 43-3216% -177BetOnline | |||||||
PITM. Keller (R) 39-390% +113BetOnline | |||||||
MIAS. Alcantara (R) 40-3917% -152BetOnline | |||||||
WSHZ. Littell (R) 41-3876% +155Everygame | |||||||
CINN. Lodolo (L) 37-4037% -105BetAnything | |||||||
NYMK. Senga (R) 34-4387% -111Bookmaker | |||||||
![]() CWSS. Burke (R) 40-3733% +102Everygame | |||||||
![]() MINK. Rojas (L) 38-4279% +157Everygame | |||||||
STLK. Leahy (R) 42-3454% -108BetOnline | |||||||
![]() COLS. Sullivan (L) 31-4885% +145BetOnline | |||||||
LAAR. Johnson (R) 32-4850% +128Everygame | |||||||
![]() SDG. Canning (R) 40-3733% +101Everygame | |||||||
SFR. Ray (L) 31-4668% -135BetOnline | |||||||
NYMUndecided 34-43- - |