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The Houston Astros will visit the Chicago Cubs at Wrigley Field in Chicago, IL on May 24, 2026, in an MLB regular season game broadcasted on Marquee Sports Network. Our picks predict a 4.6 to 3.7 score favoring the Cubs, with Houston expected to cover the +1.5 spread at a 57% probability. The Cubs' hitters show moderate effectiveness against right-handed pitching, which matches the Astros' starting pitcher's profile, influencing our betting tips. Our model has shown a 60% hit rate on recent moneyline predictions, supporting the Cubs' edge in this matchup. For detailed analysis, see our MLB picks and predictions.
PITP. Skenes (R) 41-40100% -201BetOnline | |||||||
![]() DETK. Montero (R) 34-47100% -114BetAnything | |||||||
BALT. Rogers (L) 38-44100% -128BetOnline | |||||||
![]() TORP. Corbin (L) 39-4267% +102Everygame | |||||||
NYMUndecided 34-47- +142BetOnline | |||||||
BOSP. Tolle (L) 33-46100% +106Everygame | |||||||
![]() CLEJ. Cantillo (L) 42-39100% -108BetOnline | |||||||
TBN. Martinez (R) 45-33- -131Bookmaker | |||||||
![]() CWSD. Sandlin (R) 41-38- -135MyBookie | |||||||
MILJ. Misiorowski (R) 49-29- -255BetOnline | |||||||
![]() MINT. Bradley (R) 38-440% -157Bet105 | |||||||
STLM. McGreevy (R) 42-3633% -109Bookmaker | |||||||
LAAW. Ureña (R) 34-48100% +112BetOnline | |||||||
![]() SDW. Buehler (R) 42-3750% +135Everygame |