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The upcoming MLB game between the Philadelphia Phillies and Chicago Cubs is scheduled for April 21, 2026, at 7:40 PM ET. The game will be held at Wrigley Field in Chicago, IL, and broadcast on Marquee Sports Network. Our picks favor Philadelphia with a predicted score of 4 to 3 against the Cubs. Philadelphia has a 61.5% probability of covering the +1.5 spread, while the Cubs' chance stands at 38.5%. Considering the starting pitchers and hitters' performance against right-handed pitching, betting tips suggest favoring Philadelphia's spread. Our prediction model has been profitable recently, with a high EV and a solid hit rate in the last 10 games. For more detailed analysis, visit our MLB picks page.
PITP. Skenes (R) 41-40100% -201BetOnline | |||||||
![]() DETK. Montero (R) 34-47100% -114BetAnything | |||||||
BALT. Rogers (L) 38-44100% -128BetOnline | |||||||
![]() TORP. Corbin (L) 39-4267% +102Everygame | |||||||
NYMUndecided 34-47- +142BetOnline | |||||||
BOSP. Tolle (L) 33-46100% +106Everygame | |||||||
![]() CLEJ. Cantillo (L) 42-39100% -108BetOnline | |||||||
TBN. Martinez (R) 45-33- -131Bookmaker | |||||||
![]() CWSD. Sandlin (R) 41-38- -135MyBookie | |||||||
MILJ. Misiorowski (R) 49-29- -255BetOnline | |||||||
![]() MINT. Bradley (R) 38-440% -157Bet105 | |||||||
STLM. McGreevy (R) 42-3633% -109Bookmaker | |||||||
LAAW. Ureña (R) 34-48100% +112BetOnline | |||||||
![]() SDW. Buehler (R) 42-3750% +135Everygame |