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The upcoming MLB game on April 22, 2026, features the Philadelphia Phillies visiting the Chicago Cubs at Wrigley Field in Chicago, IL. Broadcast on NBCS-Ph and Marquee Sports Network, the Phillies face a Cubs team with a predicted score of 4.10 against Philadelphia's 3.31. Our picks favor Philadelphia +1.5 with a 58.7% probability to cover the spread. The predicted total runs are under 8.5, with a 65.7% hit rate and positive EV. Historically, our MLB predictions have shown strong profitability, with a hit rate exceeding 58% in recent games.
Philadelphia's hitters have moderate success against right-handed pitchers, while the Cubs' offense performs slightly better against lefties, impacting betting tips and parlays. For detailed analysis and additional picks, see our MLB picks and predictions.
TBC. Legumina (R) 44-3342% -136BetAnything | |||||||
PITB. Chandler (R) 40-4067% +135Everygame | |||||||
SFL. Roupp (R) 33-4658% -117Bookmaker | |||||||
![]() DETT. Melton (R) 34-4665% -104Bookmaker | |||||||
WSHC. Cavalli (R) 41-4067% +155Everygame | |||||||
![]() TORK. Gausman (R) 39-4117% -126Heritage | |||||||
NYMF. Peralta (R) 34-4620% -102Bookmaker | |||||||
BOSC. Early (L) 32-4666% +145Everygame | |||||||
STLM. McGreevy (R) 42-3611% -129BetOnline |