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Before the showdown between the Pittsburgh Pirates and Chicago Cubs at PNC Park in Pittsburgh, PA, on September 15, 2025, anticipation is building. Both teams are battling to climb up the MLB standings, making this a crucial game. Our picks suggest the Cubs have a strong chance to win, with a predicted score of 5.74 to 3.24. This prediction is backed by the Cubs' recent performance against right-handed pitchers, which has been impressive. Meanwhile, the Pirates have struggled against similar matchups, which could play a significant role in the outcome. The Cubs are favored with a 60.42% chance to cover the -1.5 spread. Catch the action live on Sportsnet PT. For more insights, check out our MLB picks page. Ready to make a smart bet? Start your OddsTrader Turbo subscription.
MIAJ. Junk (R) 11-1341% -135BetOnline | |||||||
![]() CLET. Bibee (R) 14-1118% -147Bookmaker | |||||||
TBN. Martinez (R) 12-1159% -133Bet105 | |||||||
KCM. Wacha (R) 8-166% -130Everygame | |||||||
LAAJ. Soriano (R) 11-1423% -142BetAnything | |||||||
SEAL. Gilbert (R) 10-1536% -175BetOnline | |||||||
![]() DETC. Mize (R) 12-1285% -129BetOnline | |||||||
WSHZ. Littell (R) 11-1396% +133Bookmaker | |||||||
BOSR. Suarez (L) 9-1477% +126Everygame | |||||||
NYMC. Holmes (R) 7-160% -140Heritage | |||||||
![]() CHCM. Boyd (L) 14-919% -162Bet105 | |||||||
![]() TEXJ. Leiter (R) 12-1157% +102Bookmaker | |||||||
![]() COLT. Sugano (R) 9-1589% +140Everygame | |||||||
![]() AZE. Rodriguez (L) 13-106% -136Heritage | |||||||
SFT. Mahle (R) 10-1392% +186Bookmaker |