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The upcoming MLB showdown on September 16, 2025, between the Chicago Cubs and the Pittsburgh Pirates at PNC Park in Pittsburgh, PA, promises a thrilling evening of baseball action. With the Cubs recently dominating the Pirates 4-0, the Pirates are eager to regain their footing on their home turf. Currently, the Cubs are favored with a 73.8% win probability, while the Pirates stand at 26.2%. The predicted score leans towards a 5.57-3.16 victory for the Cubs. Our top pick is the Cubs at +1.5 on the point spread, boasting a 59.9% hit rate. Given the Cubs' recent form, this game is set to be a spectacle. Catch all the action on Sportsnet PT. For more MLB picks, visit our MLB picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
Our prediction model has been profitable in the last 10 games for the Cubs, winning 6 of them. With the Cubs' hitters performing well against right-handed pitchers, they are well-positioned to take advantage of the Pirates' pitching lineup. The predicted total score is 8.74, suggesting a bet on the over 7 market, which has a 56.8% hit rate.
![]() CLEP. Messick (L) 13-1122% -133Everygame | |||||||
MIAC. Paddack (R) 11-1230% -109BetAnything | |||||||
![]() DETK. Montero (R) 12-1116% -106BetAnything | |||||||
TBS. Matz (L) 12-1076% +103BetOnline | |||||||
WSHF. Griffin (L) 10-1373% +133Everygame | |||||||
BOSC. Early (L) 9-1351% -121Everygame | |||||||
NYMN. McLean (R) 7-1525% -152BetOnline | |||||||
![]() CHCS. Imanaga (L) 13-916% -125Bookmaker | |||||||
KCK. Bubic (L) 7-1612% -116Bet105 | |||||||
![]() TEXK. Rocker (R) 11-1150% -106Bet105 | |||||||
![]() COLJ. Herget (R) 9-1478% +130Bookmaker | |||||||
LAAJ. Kochanowicz (R) 11-1380% -109BetAnything | |||||||
SEAL. Castillo (R) 10-1426% -153Everygame | |||||||
![]() AZM. Kelly (R) 13-913% -142Bet105 | |||||||
SFL. Roupp (R) 9-1390% +157Everygame | |||||||
MIAJ. Junk (R) 11-12- -121BetOnline | |||||||
![]() CLET. Bibee (R) 13-11- -128MyBookie | |||||||
TBN. Martinez (R) 12-10- -125BetOnline | |||||||
KCM. Wacha (R) 7-16- -125MyBookie | |||||||
LAAJ. Soriano (R) 11-13- -143BetOnline | |||||||
SEAL. Gilbert (R) 10-14- -185BetOnline | |||||||
![]() DETC. Mize (R) 12-11- -130BetOnline | |||||||
WSHZ. Littell (R) 10-13- +134BetOnline | |||||||
BOSR. Suarez (L) 9-13- +119Heritage | |||||||
![]() COLT. Sugano (R) 9-14- - | |||||||
![]() AZE. Rodriguez (L) 13-9- -138BetOnline | |||||||
SFT. Mahle (R) 9-13- +174Heritage |