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On September 27, 2025, the St. Louis Cardinals will face off against the Chicago Cubs at Wrigley Field in Chicago, IL. This Major League Baseball matchup promises to be a thrilling encounter. The Cubs, coming off a dominant 12-1 victory over the Cardinals, are looking to replicate their success. With the Cubs as the favorites, the run line is set at -1.5 -110, while the Cardinals are at +1.5 -110. The game will be broadcasted on FDSMW, offering fans an opportunity to watch the action live. The odds have shifted slightly from the opening, with the Cubs' moneyline at -170 and the Cardinals at +143, indicating a strong confidence in the Cubs' performance. Bettors should consider these odds and the recent form of both teams when placing their bets. For more insights and to place your wagers, check out our MLB odds page. Additionally, Caesars Sportsbook offers competitive odds for this game. Ready to make informed bets? Start your OddsTrader Turbo subscription now and take advantage of the latest insights.
![]() CLEP. Messick (L) 13-1122% -133Everygame | |||||||
MIAC. Paddack (R) 11-1226% -109BetAnything | |||||||
![]() DETK. Montero (R) 12-1117% -106BetAnything | |||||||
TBS. Matz (L) 12-1076% +103BetOnline | |||||||
WSHF. Griffin (L) 10-1375% +127Bet105 | |||||||
BOSC. Early (L) 9-1353% -119BetAnything | |||||||
NYMN. McLean (R) 7-1524% -152BetOnline | |||||||
![]() CHCS. Imanaga (L) 13-914% -125Bookmaker | |||||||
KCK. Bubic (L) 7-1612% -116Bet105 | |||||||
![]() TEXK. Rocker (R) 11-1140% -105Bet105 | |||||||
![]() COLJ. Herget (R) 9-1481% +133Bookmaker | |||||||
LAAJ. Kochanowicz (R) 11-1380% -109BetAnything | |||||||
SEAL. Castillo (R) 10-1427% -153Everygame | |||||||
![]() AZM. Kelly (R) 13-910% -142Bet105 | |||||||
SFL. Roupp (R) 9-1392% +157Everygame | |||||||
MIAJ. Junk (R) 11-12- -121BetOnline | |||||||
![]() CLET. Bibee (R) 13-11- -128MyBookie | |||||||
TBN. Martinez (R) 12-10- -125BetOnline | |||||||
KCM. Wacha (R) 7-16- -125MyBookie | |||||||
LAAJ. Soriano (R) 11-13- -143BetOnline | |||||||
SEAL. Gilbert (R) 10-14- -185BetOnline | |||||||
![]() DETC. Mize (R) 12-11- -130BetOnline | |||||||
WSHZ. Littell (R) 10-13- +134BetOnline | |||||||
BOSR. Suarez (L) 9-13- +119Heritage | |||||||
![]() AZE. Rodriguez (L) 13-9- -150BetOnline | |||||||
SFT. Mahle (R) 9-13- +174Heritage |