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The upcoming MLB matchup on March 21, 2026, features the Chicago White Sox facing the Cincinnati Reds at Goodyear Ballpark in Goodyear, AZ. This game is scheduled for 9:05 PM ET and will be broadcast on local TV stations. Our picks and betting tips consider the Reds' advantage as the home team and the White Sox's recent form. Both teams' hitters' performance against right- or left-handed pitchers will influence the betting markets. Our prediction favors Cincinnati Reds with a close 4-3 win and a profitable moneyline bet, supported by a 60% hit rate in our last 10 MLB picks. For more in-depth analysis, visit our MLB picks and predictions page.
![]() CLEP. Messick (L) 13-1122% -133Everygame | |||||||
MIAC. Paddack (R) 11-1226% -109BetAnything | |||||||
![]() DETK. Montero (R) 12-1117% -106BetAnything | |||||||
TBS. Matz (L) 12-1076% +103Bet105 | |||||||
WSHF. Griffin (L) 10-1374% +127Bet105 | |||||||
BOSC. Early (L) 9-1355% -119BetAnything | |||||||
NYMN. McLean (R) 7-1524% -152BetOnline | |||||||
![]() CHCS. Imanaga (L) 13-914% -125Bookmaker | |||||||
KCK. Bubic (L) 7-1612% -116Bet105 | |||||||
![]() TEXK. Rocker (R) 11-1140% -105Bet105 | |||||||
![]() COLUndecided 9-1479% +133Bookmaker | |||||||
LAAJ. Kochanowicz (R) 11-1380% -109BetAnything | |||||||
SEAL. Castillo (R) 10-1427% -153Everygame | |||||||
![]() AZM. Kelly (R) 13-910% -142Bet105 | |||||||
SFL. Roupp (R) 9-1392% +157Everygame | |||||||
MIAJ. Junk (R) 11-12- -121BetOnline | |||||||
![]() CLET. Bibee (R) 13-11- -128MyBookie | |||||||
TBN. Martinez (R) 12-10- -125BetOnline | |||||||
KCM. Wacha (R) 7-16- -125MyBookie | |||||||
LAAJ. Soriano (R) 11-13- -143BetOnline | |||||||
SEAL. Gilbert (R) 10-14- -185BetOnline | |||||||
![]() DETC. Mize (R) 12-11- -130BetOnline | |||||||
WSHZ. Littell (R) 10-13- +134BetOnline | |||||||
BOSR. Suarez (L) 9-13- +119Heritage | |||||||
![]() AZE. Rodriguez (L) 13-9- -150BetOnline | |||||||
SFT. Mahle (R) 9-13- +174Heritage |