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On September 12, 2025, the Cleveland Guardians will face off against the Chicago White Sox at Progressive Field in Cleveland, OH. This MLB clash is set to be a thrilling encounter, especially for sports bettors looking to capitalize on the odds. Currently, the Cleveland Guardians are slightly favored with a moneyline of -170, while the Chicago White Sox are at +143, both available at Caesars. The run line is set at -1.5 for the Guardians at +130, and +1.5 for the White Sox at -155. The over/under is placed at 8.0, with odds of o8 +100 and u8 -120, also available at Caesars.
Since the opening, the odds have shifted slightly, indicating a stronger confidence in the Guardians' ability to secure a win. Bettors should note the impact of this shift as it reflects the changing perceptions of the teams' performances. With the game being broadcasted on CLE Sports Network, fans and bettors alike will have the chance to follow the action live.
For those looking to make informed betting decisions, understanding the current odds and how they've changed can provide valuable insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. For more details on the odds, visit our MLB odds page.
MIAJ. Junk (R) 11-1341% -135BetOnline | |||||||
![]() CLET. Bibee (R) 14-1118% -147Bookmaker | |||||||
TBN. Martinez (R) 12-1159% -133Bet105 | |||||||
KCM. Wacha (R) 8-166% -130Everygame | |||||||
LAAJ. Soriano (R) 11-1423% -142BetAnything | |||||||
SEAL. Gilbert (R) 10-1536% -175BetOnline | |||||||
![]() DETC. Mize (R) 12-1285% -129BetOnline | |||||||
WSHZ. Littell (R) 11-1396% +133Bookmaker | |||||||
BOSR. Suarez (L) 9-1477% +126Everygame | |||||||
NYMC. Holmes (R) 7-160% -140Heritage | |||||||
![]() CHCM. Boyd (L) 14-919% -162Bet105 | |||||||
![]() TEXJ. Leiter (R) 12-1157% +102Bookmaker | |||||||
![]() COLT. Sugano (R) 9-1589% +140Everygame | |||||||
![]() AZE. Rodriguez (L) 13-106% -136Heritage | |||||||
SFT. Mahle (R) 10-1392% +186Bookmaker |