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Get ready for a thrilling MLB showdown as the San Diego Padres take on the Chicago White Sox on September 21, 2025, at Rate Field in Chicago, IL. This game promises excitement as both teams aim to showcase their prowess. The Padres, being the favorites, have a moneyline of -178, while the White Sox stand at +150. The run line is set at -1.5 -105 for the Padres and +1.5 -115 for the White Sox. With the over/under at 8.0, bettors have plenty to consider.
For those looking to make informed bets, understanding these odds is crucial. The Padres' strong performance this season makes them a formidable opponent, yet the White Sox, playing at home, have a chance to upset the odds. With the game being broadcasted on SDPA, fans and bettors alike can tune in for the action.
Changes in the opening odds reflect the dynamic nature of MLB betting. Initially, the Padres were less favored, but recent performances have shifted the odds. This game is a part of the regular MLB season, making it a must-watch and bet. Ready to make smarter bets? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook. For the latest MLB odds, visit our MLB odds page.
![]() CLEP. Messick (L) 13-1118% -145Bookmaker | |||||||
MIAC. Paddack (R) 11-1224% -110Bet105 | |||||||
![]() DETK. Montero (R) 12-1125% -107Bet105 | |||||||
TBS. Matz (L) 12-1069% +101BetOnline | |||||||
WSHF. Griffin (L) 10-1376% +138Bookmaker | |||||||
BOSC. Early (L) 9-1348% -122Bet105 | |||||||
NYMN. McLean (R) 7-1521% -153Everygame | |||||||
![]() CHCS. Imanaga (L) 13-916% -127BetOnline | |||||||
KCK. Bubic (L) 7-1613% -117Bookmaker | |||||||
![]() TEXK. Rocker (R) 11-1150% -106Bet105 | |||||||
![]() COLJ. Herget (R) 9-1478% +130Everygame | |||||||
LAAJ. Kochanowicz (R) 11-1378% -109BetAnything | |||||||
SEAL. Castillo (R) 10-1423% -153Everygame | |||||||
![]() AZM. Kelly (R) 13-911% -143Bet105 | |||||||
SFL. Roupp (R) 9-1392% +157Everygame | |||||||
MIAJ. Junk (R) 11-12- -121BetOnline | |||||||
![]() CLET. Bibee (R) 13-11- -128MyBookie | |||||||
TBN. Martinez (R) 12-10- -125BetOnline | |||||||
KCM. Wacha (R) 7-16- -125MyBookie | |||||||
LAAJ. Soriano (R) 11-13- -141BetOnline | |||||||
SEAL. Gilbert (R) 10-14- -185BetOnline | |||||||
![]() DETC. Mize (R) 12-11- -130BetOnline | |||||||
WSHZ. Littell (R) 10-13- +134BetOnline | |||||||
BOSR. Suarez (L) 9-13- +119Heritage | |||||||
![]() COLT. Sugano (R) 9-14- - | |||||||
![]() AZE. Rodriguez (L) 13-9- -138BetOnline | |||||||
SFT. Mahle (R) 9-13- +174Heritage |