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The upcoming MLB game on March 22, 2026, features the Seattle Mariners visiting the Chicago White Sox at Camelback Ranch in Phoenix, AZ. Broadcast on Seam, this matchup provides intriguing betting opportunities given the teams' recent performances. Our picks and predictions favor the White Sox to cover the spread with a predicted score of 4-2. The Mariners have struggled against right-handed pitching, which benefits the White Sox's right-handed starters. Our prediction model has achieved a 65% hit rate and positive EV in the last 10 games, particularly excelling in moneyline bets. For detailed analysis, visit our MLB picks page.
![]() CLEP. Messick (L) 13-1122% -133Everygame | |||||||
MIAC. Paddack (R) 11-1226% -109BetAnything | |||||||
![]() DETK. Montero (R) 12-1117% -106BetAnything | |||||||
TBS. Matz (L) 12-1075% +103Bet105 | |||||||
WSHF. Griffin (L) 10-1373% +127Bet105 | |||||||
BOSC. Early (L) 9-1355% -119BetAnything | |||||||
NYMN. McLean (R) 7-1526% -152BetOnline | |||||||
![]() CHCS. Imanaga (L) 13-914% -122Bookmaker | |||||||
KCK. Bubic (L) 7-1612% -117Bookmaker | |||||||
![]() TEXK. Rocker (R) 11-1150% -105Bet105 | |||||||
![]() COLUndecided 9-1478% +133JustBet | |||||||
LAAJ. Kochanowicz (R) 11-1381% -110BetOnline | |||||||
SEAL. Castillo (R) 10-1420% -153Everygame | |||||||
![]() AZM. Kelly (R) 13-910% -142Bet105 | |||||||
SFL. Roupp (R) 9-1391% +157Everygame | |||||||
MIAJ. Junk (R) 11-12- -121BetOnline | |||||||
![]() CLET. Bibee (R) 13-11- -128MyBookie | |||||||
TBN. Martinez (R) 12-10- -125BetOnline | |||||||
KCM. Wacha (R) 7-16- -125MyBookie | |||||||
LAAJ. Soriano (R) 11-13- -143BetOnline | |||||||
SEAL. Gilbert (R) 10-14- -180BetOnline | |||||||
![]() DETC. Mize (R) 12-11- -130BetOnline | |||||||
WSHZ. Littell (R) 10-13- +134BetOnline | |||||||
BOSR. Suarez (L) 9-13- +119Heritage | |||||||
![]() AZE. Rodriguez (L) 13-9- -150BetOnline | |||||||
SFT. Mahle (R) 9-13- +171BetOnline |