Cincinnati Reds vs. St. Louis Cardinals: MLB Showdown at Busch Stadium

On June 22, 2025, at Busch Stadium in St. Louis, the Cincinnati Reds face off against the St. Louis Cardinals. This thrilling MLB matchup is set to start at 14:15 ET and will be broadcast live on FDSOH. In their last matchup on June 21, the Cardinals narrowly defeated the Reds 6-5 in an intense game. Both teams are eager to improve their standings, with the Reds holding a 41-36-0 against the spread record, and the Cardinals at 42-35-0, as seen on our MLB standings page. Andrew Abbott (L), with a remarkable 1.844 ERA, will start for Cincinnati, while Miles Mikolas (R), holding a 4.355 ERA, pitches for St. Louis. The odds reflect a balanced game, with both teams at -110 on the 2way line. The point spread favors the Reds slightly at +1.5, and the total points are set at 9.5, making it an intriguing betting opportunity for fans. The Reds' recent performance includes a mix of wins and losses, whereas the Cardinals have shown consistency at home. Key players like Cincinnati's Tyler Stephenson and St. Louis' Nolan Arenado are expected to make significant impacts. With a dynamic lineup and strategic plays, this game promises excitement. Don't miss the action at Busch Stadium, where every pitch could change the course of the game.