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The Cincinnati Reds host the St. Louis Cardinals at Great American Ball Park in Cincinnati, OH on May 23, 2026. This MLB regular season matchup airs on FOX at 7:15 PM ET. Our picks favor Cincinnati with a predicted score of 5 to 3.57 and a slight edge on the moneyline at 64.8% probability. The Cardinals hold a marginal advantage in covering the +1.5 spread at 50.8%, while the under 9.5 total shows a strong 62.4% hit rate. Cincinnati's hitters have historically performed well against right-handed pitchers, which aligns with our betting tips for this game. Our MLB picks have shown a profitable trend recently, with the American Totals market posting a high EV and consistent cover percentage. For more detailed insights, visit our MLB picks page.
MIAE. Pérez (R) 41-3969% +118Everygame | |||||||
![]() CWSE. Fedde (R) 41-3740% +108Everygame | |||||||
![]() COLK. Freeland (L) 31-49100% +155Everygame | |||||||
LAAJ. Soriano (R) 33-4837% -119Bet105 | |||||||
TBG. Jax (R) 43-3314% -144Bookmaker | |||||||
![]() DETT. Skubal (L) 34-4521% -137BetOnline | |||||||
PITB. Ashcraft (R) 39-4033% -111BetOnline | |||||||
WSHM. Mikolas (R) 41-3967% +122Everygame | |||||||
![]() TORT. Yesavage (R) 39-4011% -150BetOnline | |||||||
CINR. Lowder (R) 37-4190% +130Everygame | |||||||
NYMS. Manaea (L) 34-44- +106Bookmaker | |||||||
![]() MINJ. Ryan (R) 38-4392% +157Everygame | |||||||
STLM. Liberatore (L) 42-35- -110Everygame | |||||||
![]() SDJ. Sears (L) 41-3786% +122Bookmaker | |||||||
SFT. Mahle (R) 32-4687% +115Everygame |