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Get ready for a thrilling MLB showdown as the Detroit Tigers take on the Cleveland Guardians at Comerica Park in Detroit, MI, on September 16, 2025. This matchup promises to be a captivating display of baseball prowess, with both teams eager to secure a win. As the Tigers host the Guardians, fans can expect an intense battle on the field.
Currently, the Tigers are favored with a Moneyline of -145, while the Guardians are the underdogs with +122. The run line is set at -1.5 -110 for the Tigers and +1.5 -110 for the Guardians, making it an intriguing choice for bettors. The over/under is set at o8 -115, indicating a potentially high-scoring affair.
For those looking to place bets, understanding the betting odds and lines can provide a significant edge. The Tigers' current odds reflect their recent performance and home advantage, while the Guardians' odds present a tempting opportunity for those betting on the underdog. Keep an eye on the MLB standings and MLB odds page for the latest updates and best betting options.
Don't miss the action on September 16, 2025, broadcast on cleg. Ready to bet smarter? Start your OddsTrader Turbo subscription or check out our Caesars Sportsbook review for the best odds available.
MIAJ. Junk (R) 11-1341% -135BetOnline | |||||||
![]() CLET. Bibee (R) 14-1118% -147Bookmaker | |||||||
TBN. Martinez (R) 12-1159% -133Bet105 | |||||||
KCM. Wacha (R) 8-166% -130Everygame | |||||||
LAAJ. Soriano (R) 11-1423% -142BetAnything | |||||||
SEAL. Gilbert (R) 10-1536% -175BetOnline | |||||||
![]() DETC. Mize (R) 12-1285% -129BetOnline | |||||||
WSHZ. Littell (R) 11-1396% +133Bookmaker | |||||||
BOSR. Suarez (L) 9-1477% +126Everygame | |||||||
NYMC. Holmes (R) 7-160% -140Heritage | |||||||
![]() CHCM. Boyd (L) 14-919% -162Bet105 | |||||||
![]() TEXJ. Leiter (R) 12-1157% +102Bookmaker | |||||||
![]() COLT. Sugano (R) 9-1589% +140Everygame | |||||||
![]() AZE. Rodriguez (L) 13-106% -136Heritage | |||||||
SFT. Mahle (R) 10-1392% +186Bookmaker |