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Jun 28, 2025 4:10 PM EDT
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St. Louis Cardinals vs Cleveland Guardians: Game Preview & Betting Insights
Updated:Jun 28, 2025 2:20 AM EDT
In a thrilling matchup, the St. Louis Cardinals take on the Cleveland Guardians at Progressive Field, Cleveland, on June 28, 2025, at 4:10 PM EST. The last encounter between these teams saw St. Louis dominate with a 5-0 win, as seen in their last matchup. This game will be broadcast live on FDSMW, providing fans a chance to witness the action unfold in real-time.
The Cardinals, with a strong ATS record of 45-38-0, have been formidable, especially away from home, as detailed on our MLB standings page. Miles Mikolas, starting pitcher for St. Louis, brings a 4.306 ERA, aiming to maintain his team's momentum. Meanwhile, the Guardians, led by Slade Cecconi with a 3.375 ERA, look to bounce back, despite their recent struggles, holding a 41-39-0 ATS record. Cleveland's home performance will be pivotal, with their ATS as home standing at 18-20.
For bettors, the point spread favors Cleveland at -1.5 with odds of +170, while the total points line is set at 8.5, indicating a potentially tight game. The Guardians' recent form, losing to the Cardinals and struggling against Toronto, highlights their need for a strategic overhaul. The Cardinals, winning four of their last five, capitalize on their offensive prowess and fielding strength.
Injury updates reveal Cleveland's José Ramírez remains day-to-day, which could impact their lineup significantly. St. Louis's consistent fielding, with a fielding percentage of .99, poses a challenge for Cleveland's hitters. As the game approaches, fans and bettors will keenly watch how these dynamics play out, influencing their betting strategies.
M. Mikolas (R)STL - Pitcher
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S. Cecconi (R)CLE - Pitcher
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- LAST 5 GAMES
- LAST 3 VS ST. LOUIS
Game
Score
ATS
O/U
All
- All
- 1st 5
80-82 (17th)Against the Spread91-74 (4th)
40-41Home / Away42-42
-7.7Units+10.4
-9.9Home / Away-0.3
-4.76%ROI6.28%
-12.21%Home / Away-0.39%
78-84 (20th)Win - Loss89-76 (10th)
34-47Home / Away46-38
81-74-7Over / Under69-87-9
42-35-4Home / Away38-42-3
HEAD TO HEAD
33.5At Bat32.8
4.3Runs4
8.2Hits7.4
0.9Home Runs1
4Runs Batted In3.8
2.8Base on Balls2.9
8.2Strikeouts8.3
0.5Stolen Base0.8
0.2Batting Average0.2
0.1Intentional Walks0.2
0.5Hit by Pitch0.4
0.2Sacrifice Hit0.2
0.2Sacrifice Fly0.3
12.7Total Bases12.2
2.6Extra Base Hits2.6
0.7Ground into DP0.5
4.3Earned Run Average3.7
8.8Innings Pitched8.9
8.9Hits Allowed8
4.7Total Runs4
4.2Earned Runs3.7
1Home Runs Allowed1
2.7Walks3.1
7.5Strikeouts8.5
1.3WHIP1.3
0.1Shutout0.1
0.1Intentional Walks0.1
0.6Hold0.7
0.6Ground into DP0.6
9.4Ground ball Outs7.9
4.9Fly Outs5
0.3Wild Pitches0.3
0Balks0.1
0.1Pickoffs0.1
142.3Pitches Thrown146.9
36.6Total Chances35.5
26.5Putout26.7
9.6Total Assists8.2
0.5Errors0.6
0.8Double Plays0.7
0.7Stolen Bases Allowed0.7
0.2Caught Stealing (C)0.3
0.2Stolen Base %0.3
0.1Passed Balls0
0.3Wild Pitches0.3
1Fielding Percentage1
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Money
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- Game
- 1st 5
MLBTue 04/21
 CLEP. Messick (L) 13-1118% -145Bookmaker | |||||||
 MIAC. Paddack (R) 11-1224% -111BetOnline | |||||||
 DETK. Montero (R) 12-1119% -107BetOnline | |||||||
 TBS. Matz (L) 12-1068% +101BetOnline | |||||||
 WSHF. Griffin (L) 10-1376% +138Bookmaker | |||||||
 BOSC. Early (L) 9-1348% -121Bet105 | |||||||
 NYMN. McLean (R) 7-1521% -153Everygame | |||||||
 CHCS. Imanaga (L) 13-916% -127BetOnline | |||||||
 KCK. Bubic (L) 7-1613% -117Bookmaker | |||||||
 TEXK. Rocker (R) 11-1150% -106Bet105 | |||||||
 COLJ. Herget (R) 9-1477% +130Everygame | |||||||
 LAAJ. Kochanowicz (R) 11-1378% -109BetAnything | |||||||
 SEAL. Castillo (R) 10-1423% -153Everygame | |||||||
 AZM. Kelly (R) 13-911% -143Bet105 | |||||||
 SFL. Roupp (R) 9-1391% +157Everygame | |||||||
MIAJ. Junk (R) 11-12- -121BetOnline | |||||||
CLET. Bibee (R) 13-11- -128MyBookie | |||||||
TBN. Martinez (R) 12-10- -125BetOnline | |||||||
KCM. Wacha (R) 7-16- -125MyBookie | |||||||
LAAJ. Soriano (R) 11-13- -141BetOnline | |||||||
SEAL. Gilbert (R) 10-14- -185BetOnline | |||||||
DETC. Mize (R) 12-11- -130BetOnline | |||||||
WSHZ. Littell (R) 10-13- +134BetOnline | |||||||
BOSR. Suarez (L) 9-13- +119Heritage | |||||||
COLT. Sugano (R) 9-14- - | |||||||
AZE. Rodriguez (L) 13-9- -138BetOnline | |||||||
SFT. Mahle (R) 9-13- +174Heritage |
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