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The Cleveland Guardians will face the St. Louis Cardinals on April 13, 2026, at Busch Stadium in St. Louis, MO. This MLB regular-season game is broadcast on Card. The current odds favor Cleveland with a Moneyline of -111, while St. Louis holds +101. The run line has shifted from opening odds of -1.5 -110 for Cleveland to -1.5 +147 currently, indicating increased confidence in the Guardians. Totals are set at 8 runs, with the over at -115 and under at -105. This data-driven analysis highlights key betting lines ahead of the matchup. For more details, visit the MLB odds page.
TBC. Legumina (R) 44-3344% -135BetAnything | |||||||
PITB. Chandler (R) 40-4071% +135Everygame | |||||||
SFL. Roupp (R) 33-4659% -122JustBet | |||||||
![]() DETT. Melton (R) 34-4667% -104JustBet | |||||||
WSHC. Cavalli (R) 41-4070% +163Bookmaker | |||||||
![]() TORK. Gausman (R) 39-4119% -144Bet105 | |||||||
NYMF. Peralta (R) 34-4618% -102Bookmaker | |||||||
BOSC. Early (L) 32-4670% +145Everygame | |||||||
STLM. McGreevy (R) 42-3612% -129BetOnline |