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Before the big MLB showdown on August 28, 2025, between the Pittsburgh Pirates and the St. Louis Cardinals at Busch Stadium in St. Louis, MO, fans and bettors alike are buzzing with anticipation. The Cardinals have shown a strong home performance this season, but the Pirates are no strangers to pulling off surprising upsets. With the game being broadcast on Sportsnet PT, you won't want to miss the action. Our picks suggest a slight edge for St. Louis, with a predicted score of 5.33 to 4.51 in their favor. The Cardinals have a 58.7% chance to win, which is bolstered by their recent form against right-handed pitchers. On the other side, Pittsburgh's hitters have struggled against similar matchups. Our betting tips point towards the over 8.5 market as a profitable option, given our predicted total score of 9.84. Historically, our American Totals predictions have had a solid hit rate, making this a bet worth considering. For more detailed MLB picks, check out our MLB picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
![]() CLEP. Messick (L) 13-1122% -133Everygame | |||||||
MIAC. Paddack (R) 11-1230% -109BetAnything | |||||||
![]() DETK. Montero (R) 12-1116% -106BetAnything | |||||||
TBS. Matz (L) 12-1076% +103BetOnline | |||||||
WSHF. Griffin (L) 10-1373% +136BetOnline | |||||||
BOSC. Early (L) 9-1351% -121Everygame | |||||||
NYMN. McLean (R) 7-1524% -152BetOnline | |||||||
![]() CHCS. Imanaga (L) 13-916% -125Bookmaker | |||||||
KCK. Bubic (L) 7-1612% -116Bet105 | |||||||
![]() TEXK. Rocker (R) 11-1150% -106Bet105 | |||||||
![]() COLJ. Herget (R) 9-1478% +130Bookmaker | |||||||
LAAJ. Kochanowicz (R) 11-1380% -108Bookmaker | |||||||
SEAL. Castillo (R) 10-1426% -153Everygame | |||||||
![]() AZM. Kelly (R) 13-912% -142Bet105 | |||||||
SFL. Roupp (R) 9-1390% +157Everygame | |||||||
MIAJ. Junk (R) 11-12- -121BetOnline | |||||||
![]() CLET. Bibee (R) 13-11- -128MyBookie | |||||||
TBN. Martinez (R) 12-10- -125BetOnline | |||||||
KCM. Wacha (R) 7-16- -125MyBookie | |||||||
LAAJ. Soriano (R) 11-13- -143BetOnline | |||||||
SEAL. Gilbert (R) 10-14- -185BetOnline | |||||||
![]() DETC. Mize (R) 12-11- -130BetOnline | |||||||
WSHZ. Littell (R) 10-13- +134BetOnline | |||||||
BOSR. Suarez (L) 9-13- +119Heritage | |||||||
![]() COLT. Sugano (R) 9-14- - | |||||||
![]() AZE. Rodriguez (L) 13-9- -138BetOnline | |||||||
SFT. Mahle (R) 9-13- +174Heritage |