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The upcoming MLB game on March 5, 2026, features the Pittsburgh Pirates facing off against the St. Louis Cardinals at LECOM Park in Bradenton, FL. This National League matchup is set to deliver exciting baseball action and intriguing betting opportunities. Our picks for this game take into account the starting pitchers' handedness, hitters' performance against right- and left-handed pitchers, and recent team form.
The Pirates and Cardinals both have strong lineups, but the Cardinals have shown a slight edge when facing right-handed pitching, which could influence the outcome depending on the starter announced. This game will be broadcast on Card TV, giving fans and bettors an excellent chance to watch the action live. Our prediction model, which has maintained a solid hit rate and positive EV in the last 10 games, suggests a close contest with the Cardinals favored to win 5-4 on the moneyline.
For bettors looking to capitalize, focusing on moneyline bets and select parlays may offer the best returns. Our picks are designed to help you make smart betting decisions by analyzing in-depth statistics and trends. Don't miss out on the latest MLB picks and expert analysis by visiting our MLB picks and predictions page to stay ahead in your betting game.
![]() CLEP. Messick (L) 13-1122% -133Everygame | |||||||
MIAC. Paddack (R) 11-1226% -109BetAnything | |||||||
![]() DETK. Montero (R) 12-1117% -106BetAnything | |||||||
TBS. Matz (L) 12-1075% +103Bet105 | |||||||
WSHF. Griffin (L) 10-1373% +127Bet105 | |||||||
BOSC. Early (L) 9-1355% -119BetAnything | |||||||
NYMN. McLean (R) 7-1526% -152BetOnline | |||||||
![]() CHCS. Imanaga (L) 13-914% -122Bookmaker | |||||||
KCK. Bubic (L) 7-1612% -117Bookmaker | |||||||
![]() TEXK. Rocker (R) 11-1150% -105Bet105 | |||||||
![]() COLUndecided 9-1478% +130Everygame | |||||||
LAAJ. Kochanowicz (R) 11-1381% -110BetOnline | |||||||
SEAL. Castillo (R) 10-1420% -153Everygame | |||||||
![]() AZM. Kelly (R) 13-910% -142Bet105 | |||||||
SFL. Roupp (R) 9-1391% +157Everygame | |||||||
MIAJ. Junk (R) 11-12- -121BetOnline | |||||||
![]() CLET. Bibee (R) 13-11- -128MyBookie | |||||||
TBN. Martinez (R) 12-10- -125BetOnline | |||||||
KCM. Wacha (R) 7-16- -125MyBookie | |||||||
LAAJ. Soriano (R) 11-13- -143BetOnline | |||||||
SEAL. Gilbert (R) 10-14- -180BetOnline | |||||||
![]() DETC. Mize (R) 12-11- -130BetOnline | |||||||
WSHZ. Littell (R) 10-13- +134BetOnline | |||||||
BOSR. Suarez (L) 9-13- +119Heritage | |||||||
![]() AZE. Rodriguez (L) 13-9- -150BetOnline | |||||||
SFT. Mahle (R) 9-13- +171BetOnline |