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The upcoming MLB game between the Pittsburgh Pirates and St. Louis Cardinals is scheduled for May 21, 2026, at 1:15 PM ET at Busch Stadium in St. Louis, MO. Broadcasted on the Cardinals' network, this matchup offers detailed betting insights. Our picks predict Pittsburgh to win with a score of approximately 4.39 to 3.75, favoring Pittsburgh on the moneyline despite a 40.44% chance to cover the -1.5 spread. The predicted total score is just over 8 runs, with the under 8 market showing a slight positive expected value. Pittsburgh's hitters have demonstrated moderate success against right-handed pitching, which aligns with the starting pitcher's profile, enhancing the betting tips for this game. Our prediction model has been profitable in recent games, winning 6 of the last 10 in similar markets, with a high EV and a solid hit rate, supporting these picks. For more detailed MLB betting strategies, visit our comprehensive MLB picks and predictions page.
![]() DETF. Valdez (L) 33-44100% +115Everygame | |||||||
TBD. Rasmussen (R) 43-310% -184Bet105 | |||||||
MIAT. Phillips (R) 40-3833% -118BetOnline | |||||||
WSHF. Griffin (L) 40-38- -111MyBookie | |||||||
![]() TORS. Bieber (R) 38-39- -115BetOnline | |||||||
CINB. Singer (R) 37-39100% +145BetOnline | |||||||
NYMK. Senga (R) 34-43100% +104Bookmaker | |||||||
![]() CWSA. Kay (L) 39-3725% +100Bet105 | |||||||
![]() MINZ. Matthews (R) 38-41100% +139BetAnything | |||||||
STLA. Pallante (R) 41-3440% -135BetOnline | |||||||
![]() COLR. Feltner (R) 30-48100% +112Bet105 | |||||||
LAAS. Aldegheri (L) 32-4750% +143BetOnline | |||||||
![]() SDM. King (R) 39-37- -102BetOnline |